Aim: The current study investigated the effects of artemisinin on heart and lung tissue against pentylenetetrazol-induced seizures in mice. For this purpose, malondialdehyde (MDA), advanced oxidation protein products (AOPP), Catalase (CAT), glutathione (GSH), peroxidase (GSH-Px) levels were evaluated both homogenates.Material Method: Swiss albino male mice (n=42) used experiment. Animals divide...

Dark neurons are seen in neurosurgical biopsies, experimental ischemia, hypoglycemia, and epilepsy. This study was aimed to investigate probable damage of amygdala due to pentylenetetrazol (PTZ) induced acute seizures in rat. Male Wistar rats were divided into control, sham, and PTZ groups. EEG recordings were performed before and after the PTZ injection in PTZ group. Dark neuron numbers in amy...

The convulsant activity of pentylenetetrazol (PTZ) , is mainly due to' its ability to selectively antagonize GABA mediated post synaptic inhibition in the mammalian brain though a direct excitatory effect on neuronal membranes cannot be ruled out as a contributory factor (1). Furthermore there are reports which indicate that 5-hydroxytryptamine (5-HT) and norepinephrine (NE) playa modulatory ro...

objective: previously, analgesic, hypnotic, and anticonvulsant effects have been suggested for rosa damascena (r. damascena). in the present study, possible anti-seizure and neuro-protective effects of hydro-alcoholic extract of r. damascena has been investigated after inducing seizures in rats by pentylenetetrazole (ptz). materials and methods: the rats were divided to five groups: (1) control...

Experiments using male CD1 mice were carried out to investigate the effects of subchronic (daily administration for 8 days) pretreatments with drugs enhancing GABAergic transmission (diazepam, 10 mg/kg, ip; gabapentin, 100 mg/kg, po; or vigabatrin, 500 mg/kg, po) on pentylenetetrazol (PTZ)-induced seizures, 24 h after the last injection. Subchronic administration of diazepam reduced latencies t...

The effect of the nootropic drug piracetam (100 mg/kg) on kindled seizures, kindling-induced learning deficits, and histological alterations due to changes in central excitability was investigated in Wistar rats. The animals were kindled by repeated i.p. injections of an initially subconvulsive dose of pentylenetetrazol (PTZ). As a control, piracetam or physiological saline was given 60 minutes...

Repeated administration of pentylenetetrazol (PTZ 30 mg/kg, thrice a week) to mice for 9 weeks and subsequent challenge of the animals with the same dose of PTZ on the last chronic dose produced chemical kindling. The mice showed myoclonic jerks, clonus, Straub’s tail, falling back response and full-blown convulsions. The anticonvulsant profile of chronic administration of BR16A (100 and 500 mg...

Background: Epilepsy is a chronic central nervous system disorder with high prevalence in modern society. Despite using common anticonvulsant drugs, its control not adequately achieved. Animal models for seizures play the leading role advancing our understanding of cellular mechanisms epilepsy. The present study was an attempt to elucidate electrophysiological mechanism effect sodium valproate ...

Cysteinyl leukotrienes (CysLTs) have been implicated in seizures and kindling; however, the effect of CysLT receptor antagonists on seizure frequency in kindled animals and changes in CysLT receptor expression after pentylenetetrazol (PTZ)-induced kindling have not been investigated. In this study, we evaluated whether the CysLT1 inverse agonist montelukast, and a classical anticonvulsant, phen...

In this communication, the effect of acute treatment with lamotrigine (LTG) and topiramate (TPM) was investigated on release of the main excitatory amino acids (EAA) such as glutamate (Glu) and aspartate (Asp) in the hippocampus of pentylenetetrazol (PTZ)-kindled freely moving rats using microdialysis. The results showed that the level of Glu and Asp significantly decreased in the PTZ-kindled e...