نتایج جستجو برای: parC
تعداد نتایج: 2335 فیلتر نتایج به سال:
objective(s): we investigated the contribution of gyra and parc mutational mechanism in decreased ciprofloxacin susceptibility of acinetobacter baumannii isolated from burn wound infections. materials and methods: ciprofloxacin susceptibility of 50 a. baumannii isolates was evaluated by disk diffusion and agar dilution methods. pcr and sequencing were performed for detection of mutation in gyra...
Objective(s): We investigated the contribution of gyrA and parC mutational mechanism in decreased ciprofloxacin susceptibility of Acinetobacter baumannii isolated from burn wound infections. Materials and Methods: Ciprofloxacin susceptibility of 50 A. baumannii isolates was evaluated by disk diffusion and agar dilution methods. PCR and sequencing were performed for detection of mutation in gyr...
Microscopy Toshio Ando,*,†,‡,§ Takayuki Uchihashi,†,‡,§ and Simon Scheuring †Department of Physics, and ‡Bio-AFM Frontier Research Center, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi 332-0012, Japan U1006 INSERM/Aix-Marseille Universite,́ Parc Scientifique et Technologique de Luminy Bat̂iment Inserm TPR2 bloc 5, 1...
چکیده pseudomonas مکانیسم اصلی مقاومت iv و ii تغییر در آنزیم هدف دارویعنی توپوایزومراز سلول باکتری نقش حیاتی دارند. این dna به فلوروکوئینولون ها، است که در تکثیر aeruginosa این آنزیم ها یعنی a تغییرات از طریق جهش در ناحیه تعیین کننده مقاومت 1 در ژن کدکننده زیرواحد رخ می دهد. parc و gyra ژن های در پژوهش حاضر، 73 جدایه از بیماران دارای عفونت زخم های سوختگی و 2 جدایه از نمونه های خون، ادرار ...
Introduction & Objective: Fluoroquinolones are essential antimicrobial agents used to treat UTIs. Clinical experiences have shown a high rate of antibiotic resistance among uropathogens. These resistance are usually the consequence of mutations involving genes encoding gyrA and parC. The aim of this study was to determine antimicrobial resistance pattern and the presence of mutations in regions...
Background & Aims: Klebsiella Pneumonia is a common cause of nosocomial infections including urinary tract, respiratory and wound infections. Several fluoroquinolones resistance mechanisms have been proposed, such as mutations in the topoisomerase IV subunits (ParC and ParE). The aim of this study was to investigate parC mutations in ciprofloxacin resistant isolates of Klebsiella Pneumonia from...
زمینه و هدف: فلوروکینولون‌ها نقش مهمی در درمان عفونت‌های سودوموناس آئروژینوزا بر عهده دارند. بنظر میرسد مهمترین مکانیسم مقاومت به فلوروکینولون‌ها جهش در ناحیه QRDR ژن های gyrA و parC باشد. هدف از این مطالعه بررسی نقش جهش های مذکور بر میزان مقاومت به سیپروفلوکساسین در ایزوله های بالینی سودوموناس آئروژینوزا میباشد. روش کار: تعداد 75 ایزوله بالینی سودوموناس آئروژینوزا از مراکز آموزشی درمانی شهر ت...
CUL7 and the p53-associated, PARkin-like cytoplasmic protein (PARC) were previously reported to form homodimers and heterodimers, the first demonstration of cullin dimerization. Although a CUL7-based SKP1/CUL1/F-box (SCF)-like complex has been observed, little is known about the existence of a PARC-based SCF-like complex and how PARC interacts with CUL7-based complexes. To further characterize ...
Background & Objective: Klebsiella pneumoniae has received attention due to a wide range of diseases and antibiotic resistance.The resistance to fluoroquinolones in gram-negative bacteria is often due to chromosomal mutations in the gyr and par genes. This research aimed at investigating the pattern of fluoroquinolone resistance and its relation with a mutation in the parC gene among clinical i...
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