background: the need to relieve pain and inflammation after periodontal surgery and the side effects of systemic drugs and advantages of topical drugs, made us to evaluate the effect of diclofenac mouthwash on periodontal postoperative pain.     methods: in this double-blind, randomized clinical trial study 20 quadrants of 10 patients(n=20) aged between 22-54 who also acted as their own control...

background tonsillectomy is a common procedure causing considerable postoperative pain. postoperative pain intensity of 60 - 70 in the scale of visual analog scale (vas) has been reported up to 3 - 4 days which could continue until 11 days after the surgery. objectives the current study aimed to compare the analgesic effect of gabapentin and diclofenac on pain after tonsillectomy with the contr...

objective: to detect whether the preoperative combined administration of rectal diclofenac and paracetamol is superior to placebo or rectal diclofenac alone for pain after abdominal hysterectomy. materials and methods: ninety female patients (american society of anesthesiologists (asa) physical status i-ii), scheduled for abdominal hysterectomy were recruited to this double blind trial and were...

this study investigated efficacy and side effects of morphine suppository for pain management after the first elective caesarean delivery in comparison to diclofenac suppository. one hundred women aged 18-40 with term pregnancies undergoing elective caesarean section for the first time participated in this prospective project. exclusion criteria included drug sensitivity, fetal malformations or...

The aim of this study was to compare the efficacy of diclofenac, for the treatment of acute pain originated by lower-limb fracture and surgery, with that of diclofenac plus B vitamins. This was a single-center, prospective, randomized, and double-blinded clinical trial. Patients with lower-limb closed fractures rated their pain on a 10 cm visual analog scale (VAS). Patients were then randomized...

Purpose This study was performed to evaluate topical 1% diclofenac/3% menthol gel in treating ankle sprain. Design In this randomized, double-blind, placebo-controlled trial, adolescents and adults with acute ankle sprain (N = 385) applied 4 g of gel containing 1% diclofenac/3% menthol (n = 117), 1% diclofenac (n = 112), 3% menthol (n = 77), or placebo (n = 75) four times daily. The primary out...

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylacetic acid class with anti-inflammatory, analgesic, and antipyretic properties. Contrary to the action of many traditional NSAIDs, diclofenac inhibits cyclooxygenase (COX)-2 enzyme with greater potency than it does COX-1. Similar to other NSAIDs, diclofenac is associated with serious dose-dependent gastrointestinal, cardi...

We studied 30 consecutive outpatients (14 men and 16 women; mean (SD) age 46 (11-8) years) with gallstone disease, confirmed by ultrasonography or radiography or at operation, who complained of biliary colic. Patients were randomly treated under double blind conditions with either 75 mg diclofenac sodium given intramuscularly or placebo and were followed up for 24 hours. All patients had given ...