نتایج جستجو برای: pa) and plasminogen activator inhibitor (pai

تعداد نتایج: 16870834  

Journal: :علوم زیستی ورزشی 0
فاطمه ملکی کارشناس ارشد فیزیولوژی ورزش دانشگاه مازندران ولی الله دبیدی روشن دانشیار دانشگاه مازندران

the aim of the present research was to study the effects of regular training and exhaustive exercise on t-pa/pai-1 complex in the blood of forty eight rats. they were divided randomly into control and experimental groups and the subgroups included the primary acute, secondary acute and 8-wk regularly trained (each group 8 rats). endurance training programs (five days a week, speed 15-22 m/min f...

Journal: :jundishapur journal of microbiology 0
yunus gurbuz infectious diseases and clinical microbiology clinics, diskapi yildirim beyazit training and research hospital, ministry of health, ankara, turkey baris ozturk infectious diseases and clinical microbiology clinics, ulucanlar training and research hospital, ministry of health, ankara, turkey; infectious diseases and clinical microbiology clinics, ulucanlar training and research hospital, ministry of health, ankara, turkey. tel: +90-5056434048, fax: +90-3123123805 emin ediz tutuncu infectious diseases and clinical microbiology clinics, diskapi yildirim beyazit training and research hospital, ministry of health, ankara, turkey irfan sencan infectious diseases and clinical microbiology clinics, diskapi yildirim beyazit training and research hospital, ministry of health, ankara, turkey gonul cicek senturk infectious diseases and clinical microbiology clinics, diskapi yildirim beyazit training and research hospital, ministry of health, ankara, turkey fatma aybala altay infectious diseases and clinical microbiology clinics, diskapi yildirim beyazit training and research hospital, ministry of health, ankara, turkey

results a total of 46 patients participated in this study. the significant differences between recovering patients and the patients who died, regarding aspartate aminotransferase (ast), creatine phosphokinase (cpk), lactate dehydrogenase (ldh), prothrombin time (pt), activated partial thromboplastin time (aptt), and thrombocyte and fibrinogen levels, were consistent with many clinical studies i...

Journal: :The Journal of Cell Biology 1991
H J Ehrlich R K Gebbink K T Preissner J Keijer N L Esmon K Mertens H Pannekoek

Vitronectin endows plasminogen activator inhibitor 1 (PAI-1), the fast-acting inhibitor of both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), with additional thrombin inhibitory properties. In view of the apparent association between PAI-1 and vitronectin in the endothelial cell matrix (ECM), we analyzed the interaction between PAI-1 and thrombin in t...

Journal: :Thrombosis and haemostasis 2006
Patrick Rossignol Eduardo Anglès-Cano Henri Roger Lijnen

The role of plasminogen activator inhibitor-1 (PAI-1) in vascular smooth muscle cell (VSMC) apoptosis mediated by plasminogen activation was studied with the use of aorticVSMC derived from mice with deficiency of PAI-1 (PAI-1 (-/-) ), tissue-type (t-PA (-/-) ) or urokinase-type (u-PA (-/-) ) plasminogen activator or from wildtype (WT) mice with corresponding genetic background. Plasminogen incu...

Journal: :Journal of clinical pathology 1994
K Leiper A Croll N A Booth N R Moore T Sinclair B Bennett

AIMS To identify the relative contribution of plasminogen activators, particularly tissue plasminogen activator (t-PA) and specific plasminogen activator inhibitors (PAI-1, PAI-2), to the fibrinolytic changes associated with various types of liver disease or severe chemical and physical damage to the liver. METHODS Platelet rich (PRP) and platelet poor plasma (PFP) from patients with alcoholi...

2012
Byung-Koo Yoon Young-Hee Kang Won-Jong Oh Kyungwon Park Dong-Yun Lee DooSeok Choi Duk-Kyung Kim YoungJoo Lee Mee-Ra Rhyu

The balance between tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) regulates fibrinolysis. PAI-1 expression increases in atherosclerotic arteries and vascular smooth muscle cells (VSMCs) are one of major constituents of atheroma. We investigated the impact of lysophosphatidylcholine (lysoPC), an active component of oxidized low-density lipoprotein, o...

Journal: :The Journal of Cell Biology 1988
R L Medcalf E Van den Berg W D Schleuning

Constitutive gene expression of four components of plasminogen activating enzyme system, urinary and tissue-type plasminogen activator (u-PA and t-PA), plasminogen activator inhibitor 1 (PAI-1) and PAI-2 in HT-1080 human fibrosarcoma cells, was modulated by the synthetic glucocorticoid dexamethasone (Dex, 10(-7) M). More than 90% of u-PA, t-PA and PAI-1 antigen was found in conditioned medium, ...

Journal: :Biochemical pharmacology 1991
K L Kole M R Gyetko R U Simpson R G Sitrin

Calcitriol-induced differentiation of U937 mononuclear phagocytes is known to have divergent effects on the synthesis of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-2 (PAI-2). In this study, we sought to determine whether calcitriol affects the expression of these proteins by modulating intermediate signal transduction involving intracellular calcium and prote...

Journal: :News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society 2002
Bernd R Binder Günter Christ Florian Gruber Nelly Grubic Peter Hufnagl Michael Krebs Judit Mihaly Gerald W Prager

Plasminogen activator inhibitor 1 (PAI-1) inhibits plasminogen activators (u-PA and t-PA) by forming stable complexes endocytosed via a low-density lipoprotein receptor superfamily member-dependent mechanism. PAI-1 circulates actively in plasma and latently in platelets but is also secreted and deposited into the matrix by several cells, where it participates in tissue repair processes.

Journal: :The European respiratory journal 1995
F Philip-Joët M C Alessi C Philip-Joët M Aillaud J R Barriere A Arnaud I Juhan-Vague

This study was designed to evaluate major fibrinolytic parameters in relation to parameters of inflammation associated with different kinds of pleural effusion. Sixty patients with pleural effusion were studied. The underlying aetiology was empyema in 10 cases, tuberculosis in 9, cancer in 31, cardiac failure in 7, and undetermined in 3. Plasminogen, plasminogen activator inhibitor 1 (PAI-1) an...

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