Background: Many recent epidemiological studies have shown that epileptic patients are more likely suffer from depression, anxiety, and irritability. However, the cellular mechanisms of epilepsy-induced psychotic behaviors are not fully elucidated. Neurotrophin receptors have been suggested to be involved in epilepsy and also in psychiatric disorders. Up-regulation of p75NTR expression and acti...

introduction: neurotrophins belong to growth factor family and their function is based on their receptors. they bind two types of receptors: p75 and tyrosine kinase. the motoneuron survival or death depends upon the neurotrophic factors. recent studies have demonstrated that axotomy in peripheral nerve induces apoptosis of motoneuron. deprenyl or selegiline is known as a drug with neuroprotecti...

Introduction: Neurotrophins belong to growth factor family and their function is based on their receptors. They bind two types of receptors: p75 and tyrosine kinase. The motoneuron survival or death depends upon the neurotrophic factors. Recent studies have demonstrated that axotomy in peripheral nerve induces apoptosis of motoneuron. Deprenyl or Selegiline is known as a drug with neuroprote...

Background: Bone marrow stromal cells (BMSC) have been successfully employed for movement deficit recovery in spinal cord injury (SCI) rat models. One of the unsettled problems in cell transplantation is the relative high proportion of cell death, specifically after neural differentiation. According to our previous studies, p75 receptor, known as the death receptor, is only expressed in BMSC in...

The low-affinity nerve growth factor receptor p75 is a stratified epithelial stem/progenitor marker of human epithelia. We found OM-1, squamous cell carcinoma (SCC) line, showed distinct cells with cluster, especially located at the center growing colony in monolayer culture. A cluster was surrounded by cytokeratin 14- and 13-expressing that settled outer margin colony. OM-1 were also capable f...

background: bone marrow stromal cells (bmsc) have been successfully employed for movement deficit recovery in spinal cord injury (sci) rat models. one of the unsettled problems in cell transplantation is the relative high proportion of cell death, specifically after neural differentiation. according to our previous studies, p75 receptor, known as the death receptor, is only expressed in bmsc in...

The p75 neurotrophin receptor, a member of the tumor necrosis factor receptor superfamily, is required as a co-receptor for the Nogo receptor (NgR) to mediate the activity of myelin-associated inhibitors such as Nogo, MAG, and OMgp. p45/NRH2/PLAIDD is a p75 homologue and contains a death domain (DD). Here we report that p45 markedly interferes with the function of p75 as a co-receptor for NgR. ...

The p75 neurotrophin receptor is a binding or signalling partner for a long list of receptors and ligands. In neurons, p75 neurotrophin receptor expression regulates the binding affinity between Trk receptors and growth-promoting neurotrophins, as well as their binding specificity (Roux and Barker, 2002). Neuronal p75 neurotrophin receptor also transduces growth inhibition conferred by myelin-d...

The p75 neurotrophin receptor (p75(NTR)) interacts with multiple ligands and coreceptors. It is thought to mediate myelin growth inhibition as part of the Nogo receptor complex, in addition to its other roles. Paradoxically, however, peripheral axons of p75(ExonIII-/-) mutant embryos are severely stunted. This inhibition of axon growth may be a result of neurite elongation defects in p75(NTR) m...