the objective of this study was to determine the chronology of changes in blood pressure in renalhypertension induced by solid plexiglass clips in rats. saw blades with the thickness of 0.21-0.22 mm wereused to make clips sized 4 × 2 × 2 mm from a piece of 2-mm thick plexiglass. rats were subjected to shamoperation or left renal arterial clipping, and 1, 2, 3 and 4 weeks later blood pressure, a...

background: we investigated coronary angiogenesis and serum vascular endothelial growth factor (vegf) and its soluble receptor-1 (sflt-1) concentrations in two-kidney one-clip (2k1c) hypertensive rats before and after reversal of hypertension. methods: the animal groups were: (i) sham-clipped for 12 weeks; (ii) 2k1c for 12 weeks; (iii) sham-clipped for 12 weeks and unclipped for 12 weeks; and (...

dihydropyridine calcium channel blockers consist one of the widely-used groups of drugs for the management of hypertension. in this study, antihypertensive effects of 5 newly synthesized derivatives of dhp was examined the in rat model of two-kidney, one-clip renal hypertension. the results showed that those compounds containing two nitroxy groups had less decreasing effect on map (men arterial...

It has been reported that immunization against tonin normalizes blood pressure, and that sialoadenectomy, during which the tonin-rich salivary glands are removed, decreases blood pressure in one-kidney, one-clip hypertension. To investigate the role of tonin on this form of hypertension further, we actively immunized one-kidney, one-clip hypertensive rabbits with tonin and measured both the blo...

The afferent renal nerves enhance sympathetic activity in the one-kidney, one-clip hypertensive rat. We have also found adenosine-sensitive nerve endings in the renal pelvis that, when stimulated, increase sympathetic activity producing hypertension. To determine whether adenosine, which is excreted when renal blood flow is reduced, activates the afferent renal nerves in one-kidney, one-clip hy...