objective: this study was planned to investigate whethercoriandrum sativum (c. sativum) is capable of protecting neurons against glucose/serum deprivation (gsd)-induced cytotoxicity. material and methods: the pc12 cells were cultivated for 24 h in standard media (high-glucose dmem containing fetal bovine serum) or for 6 h in gsd condition (glucose-free dmem, without serum) in the absence or pre...

in the mammalian, there are three ncx genes (ncx1, ncx2, ncx3), which their three proteins are differentially expressed in distinct regions of the central nervous system, where they might underlie different physiological and pathophysiological functions. ncx is a nine-transmembrane protein which is distributed in the brain widely. ncx operates in a bidirectional way, and exchanges ca2+ and na+ ...

background: epilepsy is a chief communal health problem. antiepileptic drugs only provide symptomatic treatment. walnut kernels (wk) have high concentrations of phenolic compounds, which have beneficial effects on human health because of their antioxidant and anti-atherogenic properties. the present study was designed to evaluate the efficacy of wk supplementation for the prevention of experime...

introduction: pro-inflammatory chemokines and cytokines   such as mcp-1 and il6 can activate microglial cells that has found in some neuro-inflammatory disorders. hypoxia activates cerebral endothelial cells to release these pro-inflammatory mediators. we aimed to investigate the anti-hypoxic effects of different doses of some gabaergic agents. materials and methods: we randomly divided 150 mic...

there are only a few, non-evidence based, neuroprotective strategies for treatment and prevention of brain injuries after closed head trauma. to establish new therapy strategies, a novel animal model is needed. the aim of our investigation was to link standardized small animal models and actual patient medical care. data of experimental small animal studies often cannot be transferred to cns in...

traumatic brain injury (tbi) is one of the leading causes of death in men under the age of 35 that mostly occurs due to the road accidents. current clinical treatments have not enough repair and prevention of secondary damage caused by cytotoxicity. progesterone, as a primary sex hormone, acts as neuroprotection in tbi and stroke. progesterone increases anti-oxidants and decreases inflammation ...

traumatic brain injury (tbi) is one of the most common neurological diseases with no definite treatment. erythropoietin (epo) and progesterone (prog) have been shown to have neuroprotective effects in different types of experimental brain injury models. this study was designed to determine the effect of epo, prog and combination of epo/prog on neurological outcome after traumatic brain injury. ...

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traumatic brain injuries may cause some neurological deficits, such as altered level of consciousness or coma, sensory-motor dysfunction, and seizure attacks. the neuroprotective effect of progesterone and erythropoietin has been shown in different types of brain injuries and cerebral ischemia. this study aims to evaluate the probable additional neuroprotective effects of progesterone and eryth...