Introduction: Neuropeptide Y (NPY) is the most abundant peptide present in mammals' brains. The majority of NPY-producing neurons is in arcuate and paraventricular nuclei of hypothalamus which affect hypophysiotrapic factors secretion. In this study we investigated the effect of intravenous injections of various doses of NPY on thyroxine (T4) and triiodothyronine (T3) serum concentrations. ...

Neuropeptide Y (NPY) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [158]) are activated endogenous peptides neuropeptide Y, Y-(3-36), peptide YY, PYY-(3-36) and pancreatic polypeptide (PP). The receptor originally identified Y3 has been CXCR4 chemokine recepter (originally named LESTR, [139]). y6 is a functional gene product in mouse, absent rat, but contains fram...

Methamphetamine (METH) is an illicit drug that causes neuronal apoptosis in the mouse striatum, in a manner similar to the neuronal loss observed in neurodegenerative diseases. In the present study, injections of METH to mice were found to cause the death of enkephalin-positive projection neurons but not the death of neuropeptide Y (NPY)/nitric oxide synthase-positive striatal interneurons. In ...

Neuropeptide transmitters are synthesized throughout the CNS and play important modulatory roles. After synthesis in the neuronal cell body, it is generally assumed that peptides are transported to nonspecialized sites of release. However, apart from a few cases, this scenario has not been thoroughly examined. Using wild-type and NPY(GFP) transgenic mice, we have studied the subcellular distrib...

polyethylenimine (pei) has been proposed as a non-viral vector, and has been successfully used to transfer reporter genes into the central nervous system (cns), kidneys, and lungs of adult mice. neuropeptide y (npy) is a peptide expressed in the hypothalamus and is important in the regulation of body weight. using pei combined with stereotactic microinjection, we have successfully transferred c...

PURPOSE To characterize the potential for neuropeptide Y (NPY) signaling in the retinal pigment epithelium (RPE) by identifying the NPY receptor subtypes present, determining the effect of NPY on second-messenger production and membrane conductance, and establishing the neural retina as a site of NPY gene expression. METHODS Neuropeptide Y receptors present in bovine and human RPE were identi...

Pancreatic polypeptide and neuropeptide Y share 50% amino acid homology (18 out of 36 residues), suggesting that they may have common ancestral origins. cDNA clones complementary to human mRNAs encoding pancreatic polypeptide and neuropeptide Y were used to detect specific human genomic DNA sequences in human-mouse somatic cell hybrid lines. The pancreatic polypeptide gene (PPY) segregated with...

Objective(s): Atherosclerosis is an important risk factor for coronary heart disease. Neuropeptide Y (NPY) and its receptors, located in peripheral tissue such as white adipose tissue, have been linked to obesity and fat storage. The role of NPY in atherosclerosis has not yet been fully studied, so this study was conducted to further investigate the effect of BIIE 0246, an NPY receptor antagoni...