purpose : to report a rare case of large vascularized astrocytoma on optic disc. case report : a 12-year-old boy with history of decreased vision in the left eye since 5-6 months ago was referred to the ocular oncology service at rassoul akram hospital with provisional diagnosis of retinoblastoma. on examination, visual acuity was counting fingers at 50 cm, and a 3+ relative afferent pupillary ...

PURPOSE To investigate the effect of squalamine, an antiangiogenic aminosterol, in an experimental model of iris neovascularization. METHODS Iris neovascularization was created in cynomolgus monkeys by occluding retinal veins with an argon laser and inducing persistent hypotony with a central corneal suture. Twenty-four eyes were treated in three groups. In Group 1, four eyes were injected in...

PURPOSE To assess iris neovascularization by uveal puncture of the mouse eye and determine the role of angiogenic factors during iris neovascularization. METHODS Uveal punctures were performed on BalbC mouse eyes to induce iris angiogenesis. VEGF-blockage was used as an anti-angiogenic treatment, while normoxia- and hypoxia-conditioned media from retinal pigment epithelium (RPE) cells was use...

purpose: to compare the effect of tissue plasminogen activator (tpa) and aspirin in patients with central retinal vein occlusion. methods: a prospective interventional study was conducted on patients with central retinal vein occlusion of less than 28 days' duration. patients in the tpa group received 100 μg intravitreal tissue plasminogen activator and the patients who declined intravitre...

OBJECTIVE To evaluate an antisense oligodeoxynucleotide (AS-ODN) targeted against vascular endothelial growth factor for its effects on ocular angiogenesis and its intraocular localization in a nonhuman primate model of iris neovascularization. METHODS Bilateral laser retinal vein occlusion was performed in monkeys, followed by intravitreal injections of a vascular endothelial growth factor-s...

Although abnormal iris vessels and secondary glaucoma in a patient with proliferative diabetic retinopathy was described over 8o years ago by Nettleship (i888), Salus (1928) was the first to call attention to rubeosis of the iris as a specific manifestation of long-term diabetes and to point out that the neovascularization of the iris resulted in haemorrhagic glaucoma. Neovascularization of the...

PURPOSE Diabetes mellitus aggravates carotid occlusive disease, that can manifest as ocular ischemic syndrome (OIS). Ocular manifestations and visual prognosis of OIS in diabetic patients were retrospectively analyzed. METHODS Twenty-three consecutive diabetic patients with OIS were divided into two groups according to the presence of iris neovascularization, and the clinical features were re...

PURPOSE To establish the efficacy and safety of intravitreal bevacizumab in reducing iris and anterior chamber angle neovascularization and managing neovascular glaucoma. DESIGN Prospective interventional case series. PATIENT AND METHODS Eleven eyes of 11 patients with iris and anterior chamber angle neovascularization with refractory intraocular pressure were treated with intravitreal inje...

central retinal vein occlusion (crvo) is the third most common blinding vascular retinal disorder. as there is no proven treatment for crvo, we performed this study to evaluate the effectiveness of radial optic neurotomy (ron) on visual acuity in eyes with crvo. this study was designed as an interventional case series. pars plana vitrectomy with ron was performed in 18 eyes of 16 patients with ...