background : meningitis is more common during the neonatal period than other periods of life and has a prevalence of one in 1000 live births. the similarity of its clinical manifestations with other infectious diseases makes it difficult to diagnose. the aim of the current study was to determine the relationship between age, sex, clinical signs and symptoms and laboratory test results of newbor...

considering the 50% mortality rate of neonatal septicemia associated with neutropenia and increasing resistance to antibiotics, simultaneous antibiotic therapy strategies are becoming more important. however, few studies have been performed to evaluate effectiveness of rhg-csf in the treatment of neutropenia in neonates. this randomized clinical trial was performed on 40 neutropenic neonates wi...

introduction: evaluation of the cerebrospinal fluid (csf) white blood cell (wbc) count and glucose and protein concentrations is used to assess the probability of the presence of central nervous system (cns) infection. although normal values are well established for csf cell counts and protein and glucose contents in children and adults, this is not the case for neonates. the purpose of this st...

Background: Meningitis is a common life threatening infection in neonatal period. Diagnostic value of CSF-CRP level in bacterial meningitis in children and adults has been studied worldwide, but there are limited studies on CSF-CRP in neonatal meningitis. This study conducted to assess any relation between CSF-CRP and plasma CRP levels and abnormal CSF findings in neonates suspected to meningit...

Background : Meningitis is more common during the neonatal period than other periods of life and has a prevalence of one in 1000 live births. The similarity of its clinical manifestations with other infectious diseases makes it difficult to diagnose. The aim of the current study was to determine the relationship between age, sex, clinical signs and symptoms and laboratory test results of ne...

Colony stimulating factor-1 (CSF-1) regulates the survival, proliferation, and differentiation of mononuclear phagocytes. To determine whether CSF-1 plays a role in the perinatal development of these cells, CSF-1 protein and mRNA expression in tissues and serum from fetal/neonatal mice and their mothers was analyzed. As fetal/neonatal age increased, CSF-1 concentrations rose in liver, kidney, a...

Introduction: Infections are one of the main causes of death during childhood. Epidemiologic studies in Iran showed that the incidence of neonatal sepsis was 1.8% in 1995. Moreover, the incidence of neonatal meningitis is 0.2 to 0.4 in per 1,000 live births. The aim of this study was to determine the necessity of lumbar puncture (LP) in early neonatal sepsis. Methods: In a retrospective study, ...

The neonate is uniquely susceptible to severe and overwhelming bacterial infections. One of the most important deficits in the neonatal host defense system seems to be a quantitative and qualitative deficiency of the myeloid and the phagocytic system. Future optimal therapy of neonatal sepsis may include the use of adjuvant immunologic therapy. Granulocyte colony-stimulating factor (G-CSF) has ...