background: hepatic steatosis is commonly observed in patients with chronic hepatitis c (chc). many studies indicate a relationship between steatosis and fibrosis progression. the aim of this study was to analyze the prevalence of hepatic steatosis and related factors in iranian chc patients.   methods: one hundred and fifteen consecutive patients with chc were enrolled which were treatment-naï...

aim : in the current study, we aimed at identifying independent laboratory parameter to predict liver damage. background : although liver biopsy is frequently recommended in assessing disease severity and selecting antiviral treatment candidates, it has several limitations. patients and methods : a total of 527 patients with untreated chronic hepatitis b virus infection were selected. a percuta...

BACKGROUND Grading schemes for the assessment of hepatic fibrosis and necroinflammatory activity in humans previously have been applied to dogs with chronic hepatitis. Interobserver agreement is a desirable characteristic for any histological scoring scheme. HYPOTHESIS/OBJECTIVES To assess interobserver agreement associated with pathologists using a previously published histological scoring s...

PURPOSE To assess the feasibility of texture analysis for classifying fibrosis stage and necroinflammatory activity grade in patients with chronic hepatitis C on T2-weighted (T2W), T1-weighted (T1W) and Gd-EOB-DTPA-enhanced hepatocyte-phase (EOB-HP) imaging. MATERIALS AND METHODS From April 2008 to June 2012, MR images from 123 patients with pathologically proven chronic hepatitis C were retr...

INTRODUCTION Leptin has been implicated in the pathogenesis of nonalcoholic steatohepatitis. It has also been suggested that adiponectin plays an important role in the transition from fatty liver disease to nonalcoholic steatohepatitis. OBJECTIVE To evaluate whether leptin and adiponectin levels are related to the degree of necroinflammatory activity and fibrosis in patients with nonalcoholic...

conclusions this study revealed that serum iron markers (especially ferritin and transferrin) might be used as surrogate markers for both liver fibrosis and necroinflammatory activity. patients and methods eighty five patients with untreated hepatitis c chronic infection were investigated. . results twenty one patients (24.7%) had elevated serum iron levels, and 29 subjects (34.1%) had severe l...

BACKGROUND There is positive correlation between the number of activated hepatic stellate cells and necroinflammatory activity and/or the stage of liver fibrosis in viral hepatitis. No study has investigated such a relationship with regard to the activated hepatic cells within specified zones of liver tissue in chronic C hepatitis. The aim of the present study was to correlate the level of acti...

The effect of interferon therapy on liver morphology was assessed in ten patients with serologically proven chronic hepatitis C. All these patients received 3 million units of alpha interferon three times a week. Six patients received therapy for 6 months, two patients for 12 months, one patient each for 3 and 9 months. All patients underwent a second liver biopsy 1 to 6 months after cessation ...

BACKGROUND Previous research has shown variation in the effects of patient factors, including hepatic necroinflammatory activity, on liver stiffness measurement (LSM). This prospective study attempts to identify explanatory factors for LSM in patients with chronic hepatitis C (CHC) using acoustic radiation force impulse (ARFI) technology. METHODS A cohort of 127 Taiwanese patients with CHC un...