background: enterobacteriaceae are a large group of bacteria widely distributed in nature. escherichia coli is the most com­mon cause of urinary tract infection. two amino acid substitutions, in gyra, are commonly responsible for quinolone re­sistance in e. coli . the aim of this study was molecular survey of nalidixic acid resistance e.coli isolated from patients in the codones of 83 and 87 gy...

background and objectives: typhoid is a major health problem faced by the developing countries like pakistan. more than 20 million cases are reported annually worldwide. currently fluoroquinolones are the drugs of choice to treat typhoid fever. in vivo resistance to fluoroquinolones leading to therapeutic failure is developing rapidly and is becoming a major concern for the clinicians. the obje...

A total of 24,591 nonhuman salmonella strains isolated in Germany between 1986 and 1998 were examined for their resistance to nalidixic acid by an agar diffusion method. The rate of resistance (inhibition zone, </=13 mm) ranged from 0.2% in 1986 to a peak of 14. 8% in 1990. Between 1991 and 1998 the MICs for nalidixic acid-resistant strains ranged from more than 256 microg/ml for nalidixic acid...

Ten epidemiologically related Yersinia enterocolitica clinical isolates were studied. Six isolates were nalidixic acid resistant (MIC > 512 microg/ml), with mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene, suggesting clonal dissemination of a nalidixic acid-susceptible Y. enterocolitica strain which has acquired different mutations generating resistance to nalid...

OBJECTIVE To find out the frequency of low-level quinolone-resistance in Multi-Drug Resistant (MDR) typhoid using nalidixic acid screening disc. STUDY DESIGN Descriptive study. PLACE AND DURATION OF STUDY Armed Forces Institute of Pathology, Rawalpindi, from January 2005 to December 2005. MATERIALS AND METHODS Blood was obtained from suspected cases of typhoid fever and cultured in to Bac...

background :  emerging antibacterial resistance rates and beta-lactamase producing bacteria recovered from uti is an increasing problem in different regions, limiting therapeutic options. therefore, this survey consider to use the extract and essence of the citrus aurantium (which have a so many rate of planting in iran) and also survey on extract on bacteria whose cause urinary tract infection...

Background :&nbsp; Emerging antibacterial resistance rates and beta-lactamase producing bacteria recovered from UTI is an increasing problem in different regions, limiting therapeutic options. Therefore, this survey consider to use the extract and essence of the citrus aurantium (which have a so many rate of planting in Iran) and also survey on extract on bacteria whose cause urinary tract infe...

During the 5 years of the study period (October 1999-October 2003), 110 strains of Shigella were isolated from fecal samples of patients having acute diarrheal diseases. Shigella sonnei phase 1 was the most prevalent (88/110, 80.0%) serotype. Resistance to nalidixic acid was not encountered from 1999-2002. Nalidixic acid resistance was observed in 6/13 (46.1%) of the S. sonnei phase 1 strains i...

Antimicrobial resistance of Shigella isolates in Bangladesh, during 2001-2002, was studied and compared with that of 1991-1992 to identify the changes in resistance patterns and trends. A significant increase in resistance to trimethoprim-sulphamethoxazole (from 52% to 72%, p < 0.01) and nalidixic acid (from 19% to 51%, p < 0.01) was detected. High, but unchanged, resistance to tetracycline, am...