نتایج جستجو برای: nNOS

تعداد نتایج: 2006  

Abstract Introduction: Matrix metalloproteinase 2 is one of the inflammatory mediators that is involved in nociceptive processing and its production is regulated by many inflammatory factors such as nitric oxide. We studied the role of MMP-2 on the analgesic effects of nNOS inhibitor. Methods: Considering that nitric oxide has many roles in pain processing, we studied the CSF levels of MMP-2 ...

Journal: :physiology and pharmacology 0
fatemeh khojasteh p.o.box 14115-166, tehran, iran majid hasanpour-ezati biology dept., shahed university seyed javad mirnajafi-zadeh p.o.box 14115-166, tehran, iran saeed semnanian p.o.box 14115-166, tehran, iran

abstract introduction: matrix metalloproteinase 2 is one of the inflammatory mediators that is involved in nociceptive processing and its production is regulated by many inflammatory factors such as nitric oxide. we studied the role of mmp-2 on the analgesic effects of nnos inhibitor. methods: considering that nitric oxide has many roles in pain processing, we studied the csf levels of mmp-2 af...

Journal: : 2022

The aim of the study was to identify localization, percentage and morphometric characteristics neuronal NO synthase (nNOS)-immunoreactive (IR) neurons in intramural ganglia myenteric (MP) submucous plexus (SP) large intestine rats different age groups.
 Material methods. work performed on Wistar aged 1, 10, 20, 30, 60 days 2 years using immunohistochemical methods.
 Results. nNOS-IR w...

Journal: :Jurnal Kimia Sains dan Aplikasi 2022

The global prevalence of anxiety and depression rates have increased by 25% due to the impact COVID-19 pandemic. Depression can occur an increase in NO produced nNOS enzyme. Gallic acid its derivatives be obtained from nature various biological activities. This study aimed determine potential gallic as inhibitors using molecular docking method with parameters binding energy values, RMSD specifi...

Journal: :Circulation 2010
Natalie Burkard Tatjana Williams Martin Czolbe Nadja Blömer Franziska Panther Martin Link Daniela Fraccarollo Julian D Widder Kai Hu Hong Han Ulrich Hofmann Stefan Frantz Peter Nordbeck Jan Bulla Kai Schuh Oliver Ritter

BACKGROUND We previously demonstrated that conditional overexpression of neuronal nitric oxide synthase (nNOS) inhibited L-type Ca2+ channels and decreased myocardial contractility. However, nNOS has multiple targets within the cardiac myocyte. We now hypothesize that nNOS overexpression is cardioprotective after ischemia/reperfusion because of inhibition of mitochondrial function and a reducti...

Journal: :International journal of biomedical research 2011
Chintamani N Joshi David A Tulis Richard T Miller

Efficient electron transfer and conversion of L-arginine to L-citrulline and nitric oxide (NO•) by neuronal nitric oxide synthase (nNOS) requires calmodulin (CaM) binding. The present study focused on electron transfer ability of resting state CaM-free nNOS in presence of dinitrobenzene isomers (DNBs). NADPH oxidation (NADPH ox ) and acetylated cytochrome-c reduction (AcCyt-cred ) catalyzed by ...

2011
Michelle Wehling-Henricks James G. Tidball

Survival of dystrophin/utrophin double-knockout (dko) mice was increased by muscle-specific expression of a neuronal nitric oxide synthase (nNOS) transgene. Dko mice expressing the transgene (nNOS TG+/dko) experienced delayed onset of mortality and increased life-span. The nNOS TG+/dko mice demonstrated a significant decrease in the concentration of CD163+, M2c macrophages that can express argi...

Journal: :Circulation research 2007
Natalie Burkard Adam G Rokita Susann G Kaufmann Matthias Hallhuber Rongxue Wu Kai Hu Ulrich Hofmann Andreas Bonz Stefan Frantz Elizabeth J Cartwright Ludwig Neyses Lars S Maier Sebastian K G Maier Thomas Renné Kai Schuh Oliver Ritter

The role of the neuronal NO synthase (nNOS or NOS1) enzyme in the control of cardiac function still remains unclear. Results from nNOS(-/-) mice or from pharmacological inhibition of nNOS are contradictory and do not pay tribute to the fact that probably spatial confinement of the nNOS enzyme is of major importance. We hypothesize that the close proximity of nNOS and certain effector molecules ...

Journal: :Molecular pharmacology 2004
Anwar Y Dunbar Yasuhiko Kamada Gary J Jenkins Ezra R Lowe Scott S Billecke Yoichi Osawa

It is established that neuronal NO synthase (nNOS) is ubiquitinated and proteasomally degraded. The metabolism-based inactivation of nNOS and the inhibition of heat shock protein 90 (hsp90)-based chaperones, which are known to regulate nNOS, both lead to enhanced proteasomal degradation of nNOS. The mechanism of this selective proteolytic degradation, or in essence how the nNOS becomes labilize...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Gerald A Rameau David S Tukey Elsa D Garcin-Hosfield Roseann F Titcombe Charu Misra Latika Khatri Elizabeth D Getzoff Edward B Ziff

Postsynaptic nitric oxide (NO) production affects synaptic plasticity and neuronal cell death. Ca2+ fluxes through the NMDA receptor (NMDAR) stimulate the production of NO by neuronal nitric oxide synthase (nNOS). However, the mechanisms by which nNOS activity is regulated are poorly understood. We evaluated the effect of neuronal stimulation with glutamate on the phosphorylation of nNOS. We sh...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید