Genetic abnormalities often serve as the catalyst to stimulate critical insights into normal biology. In many cases, examining such experiments of Nature explicates not only the abnormal but also serves to illustrate underlying normal principles. Within the context of myeloperoxidase biosynthesis, we have examined the impact of specific missense mutations that cause inherited myeloperoxidase de...

the charts of 27 patients with kawasaki disease (kd) admitted to nemazee hospital in shiraz from january 1991 to october 1998 were reviewed to identify the results of mean peroxidase index (mpxi) values, a measure of neutrophil staining intensity, obtained by the technicon hi analyzer (technicon instruments corp., tarrytown, ny) within the first 10 days of the illness 2 separate groups of patie...

Myeloperoxidase deficiency is the most common neutrophilic lysosomal enzyme deficiency. Case studies indicate that individuals with myeloperoxidase deficiency are not susceptible to serious infection in the absence of coexisting conditions such as diabetes mellitus. We present a case of myeloperoxidase deficiency manifesting as disseminated pustular candidal dermatitis in a nondiabetic male. Ce...

Subjects with neutrophil myeloperoxidase (MPO) deficiency have been rarely reported. In part this may be due to the lack of a simple screening technique that would detect them. With the routine use of a cytochemical leukocyte differential counter that employs MPO stains, over a 40-mo a period 8 unrelated probands with partial MPO-deficiency and one with complete deficiency were identified. Fami...

The functional properties of granulocytes in a diabetic patient deficient in myeloperoxidase (MPO) were compared with those of granulocytes in healthy subjects. The granulocytes of this patient had normal phagocytic activity. The microbicidal activity of the granulocytes was partially diminished with regard to Staphylococcus aureus and was almost nil with regard to Candida albicans. Fungicidal ...

Myeloperoxidase (MPO) is a hemoprotein expressed in azurophilic granules of neutrophils and lysosomes monocytes. It caused by mutations the MPO gene on chromosome 17 estimated to affect 1:2000-4000 people. most common inherited defect phagocytes. Microbial killing impaired patients with deficiency, but are asymptomatic, except for diabetic patients. In this article, we aimed present our diagnos...

This work was presented in part at the National Meeting of the American Federation for Clinical Research, Atlantic City, N. J., and published in abstract form (1). Received for publication 13 February 1969 antd in revised form 11 April 1969. Although lending support to the suggested bactericidal role of MPO in leukocytes, the data indicate that alternative bactericidal mechanisms, effective in ...