نتایج جستجو برای: multiple sclerosis severity score (msss)
تعداد نتایج: 1108987 فیلتر نتایج به سال:
background: the clinical course of multiple sclerosis (ms) evolves over many years. its prognosis is highly variable among affected individuals, i.e. while some suffer from early severe disabilities, others remain ambulatory and functional for many years. we used multiple sclerosis severity score (msss) and the new classification for ms severity herbert et al. introduced in 2006 according to ms...
multiple sclerosis (ms) is an inflammatory demyelinating disease of the central nervous system. it is a clinically heterogeneous disorder especially in terms of disease severity. current investigations suggest that genes and gene-gene interactions not only influence on susceptibility to ms but also affect the disease severity. in this study, we investigated the contribution of the hladrb1*1501 ...
OBJECTIVE We investigated the association between 52 risk variants identified through genome-wide association studies and disease severity in multiple sclerosis (MS). METHODS Ten unique MS case data sets were analyzed. The Multiple Sclerosis Severity Score (MSSS) was calculated using the Expanded Disability Status Scale at study entry and disease duration. MSSS was considered as a continuous ...
BACKGROUND The Multiple Sclerosis Severity Score (MSSS) is obtained by normalising the Expanded Disability Status Scale (EDSS) score for disease duration and has been a valuable tool in cross-sectional studies. OBJECTIVE To assess whether use of age rather than the inherently ambiguous disease duration was a feasible approach. METHOD We pooled disability data from three population-based coh...
Arylsulfatase A (ASA) is a lysosomal enzyme involved in catabolism of cerebroside-sulfate, major lipid constituent of oligodendrocyte membranes. Various polymorphisms in ASA gene have been described, leading to different levels of enzyme deficiency. Progressive demyelination occurs in metachromatic leukodystrophy (MLD), while the condition of ASA-pseudodeficiency (ASA-PD) is suggested to contri...
OBJECTIVE To investigate utility of a Multiple Sclerosis Severity Scale (MSSS)-based classification system for comparing African American (AA) and white American (WA) multiple sclerosis (MS) subpopulations in the New York State Multiple Sclerosis Consortium (NYSMSC) database. MSSS is a frequency-rank algorithm relating MS disability to disease duration in a large, untreated reference population...
objective: multiple sclerosis (ms) is one of the leading neurodegenerative causes of physical disability world-wide. genetic aberrations of autoimmunity pathway components have been demonstrated to significantly influence ms development. cluster of differentiation 58 (cd58) is pertained to a group of genes which had been assayed in several recent association studies. given the significance of c...
It is unclear how cognitive impairment in multiple sclerosis (MS) is influenced by physical disability, fatigue, and depression. Our aim was to identify the strongest clinical predictors for cognitive impairment in relapsing-remitting MS (RRMS) patients. The clinical risk factors included in the analysis were physical disability (EDSS), fatigue (FSS), the somatic and nonsomatic components of de...
ObjectiveThe identification of potential risk factors for disease severity is great importance in the treatment multiple sclerosis. The influence socioeconomic status on progression sclerosis (MS) sparsely investigated. Our aim was to investigate how adolescence influences later life.MethodsA total 1598 patients with from a well-defined population Norway were included. Detailed information prog...
OBJECTIVE To evaluate whether vitamin D is associated with multiple sclerosis (MS) status and disease severity in African Americans. METHODS Serum 25-hydroxyvitamin D was compared in a cross-sectional sample of 339 African Americans with MS and 342 African American controls. Correlations between disease severity (Multiple Sclerosis Severity Score [MSSS]) and 25-hydroxyvitamin D levels were so...
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