multiple sclerosis (ms) is a neuroinflammatory autoimmune disease which mediated by various molecular and cellular immune components however recent reports have shown that coagulation factors that traditionally separate from the immune system might also be involved in ms development and progression.studies on experimental autoimmune encephalomyelitis (eae) and human ms patients reports alterati...

background and objectives: multiple sclerosis (ms) is the most prevalent autoimmune disease of the central nervous system, and it has been suggested that nutrition might play a role in the etiology of ms. this study was aimed to evaluate the relationship between ms risk and intake of some macro- and micro-nutrients in tehran (iran). materials and methods: in this hospital based, case-control st...

objectives: multiple sclerosis is one of the most important and prevalent central nervous system diseases, causing disorders such as depression among affected patients. positive psychotherapy is also a new approach that can be effective in reducing the depression of these people. this study aims to investigate the efficiency of group positive psychotherapy for decreasing the depression among fe...

myelin basic protein (mbp) is one of the most important constituents of the cns myelin sheaths. it is supposed that an autoimmune response directed against mbp is crucial in the demyelination process in patients with multiple sclerosis. studies have proved that free anti-mbp level in csf of ms patients is declined when the patient entered into clinical remission. some researchers evaluate the c...

abstract introduction: multiple sclerosis (ms) is an autoimmune disease which affects the skeletal muscles and optical neural networks. weakness of ankle dorsi flexion and hip flexion muscles is commonly seen in consequence ms. the ankle foot orthosis (afo) is the most frequently prescribed orthoses to compensate for these weaknesses. it is generally believed that patients are commonly dissatis...

Summary The immunosuppressive agent has changed the clinical course of MS. Mostly,this agent, like cyclophosphamide cyclosporine A., and X-Ray of the lymphoid organ, has a lot of side effects. It should only be used in the most severe from of MS among immunosuppressive agents, Azathioprin has been used most frequently in spite of the fact that it is not very effective compared with other immun...

background : the pathophysiology of multiple sclerosis (ms) is characterized by fatigue, motor weakness, and spasticity, to name a few. ms symptoms may lead to physical inactivity associated with the development of secondary diseases. this study was to investigate the effect of regular aerobic and yoga on the quality of life of patients with ms.   methods : the present quasi-experimental study ...

conclusions corticosteroid pulse therapy in spms was effective in inflammatory process, but could not postpone or decline the neurodegenerative process and besides the imposing side effects could not result in significant improvement in edss and mri plaques number in long term. patients and methods a double blind randomized controlled clinical trial was performed on 71 patients with spms referr...

how to cite this article: najafi mr, najafi ma, nasr z. diagnosis and management of multiple sclerosis in children. iran j child neurol. summer 2016; 10(3): 13-23. abstract growing evidence indicates the safety and well toleration of treatment by disease-modifying in children suffering multiple sclerosis (ms). the treatment is not straight forward in a great number of patients, thus patients wi...