vilsmeier several diamide derivatives containing 2-chloroquinoline scaffolds were synthesized via ugi reaction of 2-chloroquinoline-3-carboxaldehydes, amines, carboxylic acids and isocyanides. the diversity of these quinolinyl ugi-adducts was increased by using 2-chloroquinoline-3-carboxylic acids as a source of acid. among them, compounds 2d, 2n, 2p, 4a, 4c and 4e displayed moderate to good an...

In this paper, the physico-chemical basics of the sectional multicomponent aerosol model SEMA are described. SEMA includes condensation and evaporation of sulphuric acid, nitric acid, hydrogen chloride, ammonia, and water vapour. The model can be applied to predictions of the chemical composition and size distribution of aqueous tropospheric secondary and marine aerosols. In SEMA, multicomponen...

Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications.The development of multicomponent reactions designed to produce elaborate biologically active compounds has become an important area of research in organic, combinatorial, and medicinal chemistry. in this Manuscript, a facile and efficient multicomponent synthesis of functional...

Caro’s acid-silicagel was found to be a mild and effective catalyst for the one –pot multicomponent condensation of benzyl, aldehydes and ammonium acetate used for synthesis of 2, 4, 5-trisubstituted imidazole derivatives under solvent–free conditions. This catalyst has several advantages such as simple work-up, low cost and reusability.

a series of 2-amino pyridine-3-carbinitrile derivatives incorporated coumarin moiety has developed via multicomponent condensation of 3-acetyl-2h-chromen-2-one, arylaldehydes, malononitrile and ammonium acetate utilizing brønsted acidic ionic liquid, (4-sulfobutyl)tris(4-sulfophenyl)phosphonium hydrogen sulfate as catalyst under solvent-free conditions. good yields, short reaction times, straig...

One-pot multicomponent condensation of β-naphthol, aromatic aldehydes, acetamide or urea in the presence of potassium hydrogen sulfate was carried out under solvent-free condition to afford amidoalkyl naphthols in 83%~96% yields.

Multicomponent condensation of 1-naphthol, malononitrile, and arylglyoxals in the presence of Mg-Al hydrotalcite under solvent-free MicroWave (MW) conditions gave a new series of 2-amino-4-aroyl-4H-benzo[h]chromene-3-carbonitriles in high yields (70-89%). The structure of all products was elucidated by their...

A series of 2-amino pyridine-3-carbinitrile derivatives incorporated coumarin moiety has developed via multicomponent condensation of 3-acetyl-2H-chromen-2-one, arylaldehydes, malononitrile and ammonium acetate utilizing Brønsted acidic ionic liquid, (4-sulfobutyl)tris(4-sulfophenyl)phosphonium hydrogen sulfate as catalyst under solvent-free conditions. Good yields, short reaction times, straig...

A new multidisciplinary synthetic approach comprising polymer-support synthesis, microwave-assisted synthesis, and multicomponent condensation facilitates synthesis of triaza-fluorenes library with a set of advantages such as rapid process, simple purification, and structural diversity in one shot. Microwave-assisted multistep synthetic protocol was used to construct the benzimidazole ring on s...