Background: Oral Lichen Planus (OLP) is a chronic autoimmune disease that could be considered as a potential premalignant status. Objective: To evaluate the miRNA-146a and miRNA-155 expression levels in patients with oral Lichen planus lesions compared to healthy subjects with normal oral mucosa. Methods: Forty patients with oral lichen planus and 18 healthy age and gender-matched controls were...

MicroRNAs are small non-coding RNAs that can regulate a variety of immune functions. MicroRNA146a (miRNA-146a) is regarded as crucial regulator posttranscriptional gene expression, suggesting role in autoimmune disorders. This study was performed to investigate association miRNAs-146a expression and its polymorphisms patient with Rheumatoid arthritis. The current includes 120 subjects classifie...

Spinal cord injury (SCI) is a catastrophic disease that induces complex cascade of cellular reactions at the local lesion area, including secondary cell death and inflammatory reactions. Accumulating evidence has showed pro- anti-inflammatory roles microRNAs (miRNAs), class small RNAs, in SCI. The present study aimed investigating effects two miRNAs, miRNA-146a miRNA-202-3p, on response after I...

MicroRNA-146a participates in spinal cord injury (SCI) recovery. Until recently, how miRNA-146a participates in SCI remained unclear. In this study, we tried to explore the roles of miRNA-146a in the recovery of SCI using a rat model. The expression of the probable target genes of miRNA-146a (including IRAK1 and TARF6) as well as proinflammation cytokines were measured until 7 days after surger...

BACKGROUND MicroRNAs (miRNAs), a class of small non-coding RNAs, are thought to serve as crucial regulators of gene expression. Dysregulated expression of miRNAs has been described in various diseases and may contribute to related pathologic processes. Our aim was to examine circulating miRNA-146a levels in newly diagnosed type 2 diabetes mellitus (new-T2DM) patients from a Chinese Han populati...

We aimed to investigate the relationship between miRNA-146a and latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) in nasopharyngeal carcinoma (NPC). The expression levels of LMP1 in 40 cases of NPC, 28 cases of chronic nasopharyngitis and NPC cell lines CNE1 and CNE1-GL (in which LMP1 was stably transfected) were detected by immunohisto...

Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was perfor...

BACKGROUND microRNA (miRNA) belongs to the non-coding RNAs family responsible for the regulation of gene expression. Renalase is a protein composed of 342 amino acids, secreted by the kidneys and possibly plays an important role in the regulation of sympathetic tone and blood pressure. The aim of the present study was to investigate plasma renalase concentration, and explore the relationship be...

Background: The goal of treatment for patients with RA is achieve to remission, or at least a state low disease activity. Exercise recommended in addition drug therapy. It has been found be effective greatly improving functionality and reducing cardiovascular risk without exacerbating Therefore, it that all should encouraged include aerobic resistant exercise training as part their routine (1)....

We indented to evaluate of the role miRNA-146a-5p expression level as a possible biomarker associated with incidence rheumatoid arthritis and detection its relevance different disease parameters. The study included 60 clinically diagnosed RA patients fulfilling 2010 American College Rheumatology / European League Against Rheumatism (ACR/EULAR) classification criteria for Rheumatoid Arthritis 45...