To the Editor: Acquired metallo-ß-lactamase determinants in Pseudomonas aeruginosa and other major bacterial pathogens are of concern for development of antimicrobial drug resistance. The carbapenemase and extended-spectrum cephalosporinase activity of metallo-ß-lactamases, as well as their resistance to ß-lactamase inhibitors, may severely limit the antimicrobial agents active against bacteria...

Background and Objectives New Delhi metallo-ß-lactamase (NDM) is a newly emerging metallo-ß-lactamases, which can destroy all β-lactams including carbapenems. Therefore, this study aimed at evaluating New Delhi metallo-ß-lactamase-1-production in clinical isolates of Klebsiella pneumoniae in Kashan, Iran. Materials and Methods In a cross-sectional study, 181 K. pneumoniae isolates were collec...

background and objectives: acinetobacter causes a wide variety of illness in debilitated and hospitalized patients. carbapenem resistance in acinetobacter is an emerging problem and is a cause of concern as many nosocomial infections with acinetobacter are resistant to most other antibiotics. the present study was aimed to study metallo-β-lactamase (mbl) production in acinetobacter species. mat...

Pseudomonas aeruginosa, an important nosocomial pathogen is difÞ cult to treat because of high antimicrobial resistance.[1] The common form of resistance is mediated by lack of drug penetration and / or carbapenem hydrolyzing ß-lactamases.[2] Detection of metallo ß lactamase (MBL)producing P. aeruginosa is crucial for the optimal treatment of patients. The present study was undertaken to study ...

Pseudomonas aeruginosa, an important nosocomial pathogen is difÞ cult to treat because of high antimicrobial resistance.[1] The common form of resistance is mediated by lack of drug penetration and / or carbapenem hydrolyzing ß-lactamases.[2] Detection of metallo ß lactamase (MBL)producing P. aeruginosa is crucial for the optimal treatment of patients. The present study was undertaken to study ...

References 1. Livermore DM. Acquired carbapenemases. J Antimicrob Chemother 1997;39:673-6. 2. Rasmussen BA, Bush K. Carbapenem-hydrolyzing ßlactamases. Antimicrob Agents Chemother 1997;41:223-32. 3. Lauretti L, Riccio ML, Mazzariol A, Cornaglia G, Amicosante G, Fontana R, et al. Cloning and characterization of blaVIM, a new integron-borne metallo-ß-lactamase gene from a Pseudomonas aeruginosa c...

64 Rev Esp Quimioter 2010;23(2):100-102 The class B metallo carbapenem-hydrolyzing ß lactamases (MBLs) are enzymes of great concern because they possess activity against all ß -lactams, except monobactams. Up to now, several members of this family of enzymes have been described (IMP, VIM, SPM-1, GIM-1, SIM-1). Most of VIM and IMP genes usually reside within class 1 integrons as gene cassettes. ...

ß-Lactams are the most widely used antibiotics, and ß-lactamases are the greatest source of resistance to them. Colorimetric tests are good, rapid, indicators of ß-lactamase production and its contingent resistance in Haemophilus, Moraxella and Neisseria spp. They can also be applied to Gram-negative bacilli but are less useful, since the usual question is not whether a ß-lactamase is produced ...