to evaluate the maternal serum dehydroepiandrosterone (dhea) sulfate levels as a factor influencing labor ‘efficiency’ at term and unsuccessful labor induction. this is a prospective study. in this study the mean (± standard error) maternal serum dhea sulfate levels of 90 singleton pregnant women in 3 groups with spontaneous labor, need for augmentation and need for induction were compared.preg...

to evaluate the maternal serum dehydroepiandrosterone sulfate level as a factor associated with the outcome of labor induction. venous blood was collected from 45 women at the initiation of labor induction. pregnancies complicated by maternal corticosteriod use, anterpartum chorioamnionitis, or cesarean delivery for indications other than arrest disorders, were excluded from analysis. in 42 wom...

Levels of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) in sera collected and frozen in J .were studied among 81 prostate cancer cases diagnosed in the following 12 years and 81 ageand race-matched controls. Although mean levels of DHEA were 1 1% lower among cases than controls and DHEA-S levels were 12% lower than among controls, no dose-response association was not...

Dehydroepiandrosterone (DHEA) and its sulfate ester, dehydroepiandrosterone sulfate (DHEAS) are the major adrenal C19 steroids in man. Concerning DHEAS many extensive studies have been reported using Zimmerman reaction and gas-liquid chromatography. Only a few papers, however, have appeared concerning DHEA. One of the causes of minute amount of information about DHEA was the complicated assay p...

BACKGROUND Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been suggested to have protective effects against cardiovascular disease, cancer, immune-modulated diseases, and aging. We examined serum concentrations of DHEA, DHEA-S, and pregnenolone sulfate (PREG-S) in patients with thyroid dysfunction. METHODS Steroids extracted with methanol from serum sample were...

CONTEXT Sulfate is critical in the biotransformation of multiple compounds via sulfation. These compounds include neurotransmitters, proteoglycans, xenobiotics, and hormones such as dehydroepiandrosterone (DHEA). Sulfation reactions are thought to be rate-limited by endogenous sulfate concentrations. The gene, SLC13A1, encodes the sodium-sulfate cotransporter NaS1, responsible for sulfate (re)a...

OBJECTIVE To determine the role of adrenal androgenic hormone precursors in female sexual function. DESIGN A review of current literature on sexual function and the androgen precursor hormone dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS). RESULT(S) The C(19) steroid DHEA is both an ovarian and adrenal androgen precursor hormone, whereas DHEAS is only synthesized i...

Both elevated urinary albumin excretion (UAE) and low serum concentrations of dehydroepiandrosterone (DHEA) have been linked with increased cardiovascular disease (CVD) mortality in men (1–5). We have recently demonstrated that serum DHEA sulfate (DHEA-S) concentrations correlated inversely with degree of UAE in men with type 2 diabetes (6). However, findings supporting a protective role of DHE...

preeclampsia is a major cause of morbidity and mortality during pregnancy. several independent investigators have demonstrated the association of androgens with hypertension. the main purpose of this study was to determine whether maternal levels of sex hormones, especially testosterone, are higher in patients with preeclampsia than in matched normotensive control subjects. serum levels of test...