BACKGROUND This study aimed at evaluating and comparing the performance of a new generation of continuous glucose monitoring (CGM) system versus other CGM systems, under daily lifelike conditions. METHODS A total of 10 subjects (7 female) were enrolled in this study. Each subject wore two Dexcom G4™ CGM systems in parallel for the sensor lifetime specified by the manufacturer (7 days) to allo...

INTRODUCTION The aim of this study was to compare the accuracy of 5 blood glucose monitoring systems (BGMSs; CONTOUR(®)PLUS [CP], Accu-Chek(®) Active [ACA], Accu-Chek(®) Performa [ACP], FreeStyle Freedom™ [FF], OneTouch(®) SelectSimple™ [OTSS]). METHODS Study staff tested fingerstick samples from 106 subjects aged ≥18 years using the 5 BGMSs. Some samples were modified to achieve blood glucos...

BACKGROUND This study evaluated differences in accuracy between the CONTOUR® NEXT EZ (EZ) blood glucose monitoring system (BGMS) and four other BGMSs [ACCU-CHEK® Aviva (ACAP), FreeStyle Freedom Lite® (FFL), ONE TOUCH® Ultra®2 (OTU2), and TRUEtrack® (TT)]. METHODS Up to three capillary blood samples (N = 393) were collected from 146 subjects with and without diabetes. One sample per subject wa...

BACKGROUND The performance of a continuous glucose monitoring (CGM) system in the early stage of development was assessed in an inpatient setting that simulates daily life conditions of people with diabetes. Performance was evaluated at low glycemic, euglycemic, and high glycemic ranges as well as during phases with rapid glucose excursions. METHODS Each of the 30 participants with type 1 dia...

BACKGROUND There has been considerable debate on what constitutes a good hypoglycemia (Hypo) detector and what is the accuracy required from the continuous monitoring sensor to meet the requirements of such a detector. The performance of most continuous monitoring sensors today is characterized by the mean absolute relative difference (MARD), whereas Hypo detectors are characterized by the numb...

BACKGROUND Continuous glucose monitoring system (CGMS) accuracy is of critical importance both in delivering therapeutic value and as a component of a closed-loop system. This study aims at assessing the differences between accuracy assessments of CGMS at home and at the clinical research center (CRC). METHODS Twelve patients with type 1 diabetes used the Dexcom® SEVEN® PLUS (DexCom, Inc.) CG...

BACKGROUND This study is aimed at comparing the performance of three continuous glucose monitoring (CGM) systems following the Clinical and Laboratory Standards Institute's POCT05-A guideline, which provides recommendations for performance evaluation of CGM systems. METHODS A total of 12 subjects with type 1 diabetes were enrolled in this study. Each subject wore six CGM systems in parallel, ...

In this paper, the Periodic Capacitated Arc Routing Problem (PCARP) is investigated. PCARP is an extension of the well-known CARP from a single period to a multi-period horizon. In PCARP, two objectives are to be minimized. One is the number of required vehicles (nv), and the other is the total cost (tc). Due to the multi-period nature, given the same graph or road network, PCARP can have a muc...

BACKGROUND Even though a Clinical and Laboratory Standards Institute proposal exists on the design of studies and performance criteria for continuous glucose monitoring (CGM) systems, it has not yet led to a consistent evaluation of different systems, as no consensus has been reached on the reference method to evaluate them or on acceptance levels. As a consequence, performance assessment of CG...

BACKGROUND Accuracy and frequency of glucose measurement is essential to achieve safe and efficacious glucose control in the intensive care unit. Emerging continuous glucose monitors provide frequent measurements, trending information, and alarms. The objective of this study was to establish the level of accuracy of continuous glucose monitoring (CGM) associated with safe and efficacious glucos...