OC144-093 is a novel substituted diarylimidazole (Mr 495) generated using the OntoBLOCK system, a solid-phase combinatorial chemistry technology, in combination with high-throughput cell-based screening. OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprot...

OC144-093 is a novel substituted diarylimidazole (Mr 495) generated using the OntoBLOCK system, a solid-phase combinatorial chemistry technology, in combination with high-throughput cell-based screening. OC144-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal carcinoma cell lines expressing P-glycoprot...

José Carlos Ferrão1,2; Mónica Duarte Oliveira2; Filipe Janela1; Henrique M. G. Martins3 1Siemens Healthcare, Rua Irmãos Siemens 1, 2720–093 Amadora, Portugal; 2CEG-IST, Centre for Management Studies of Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049–001 Lisbon, Portugal; 3Centre for Research and Creativity in Informatics, Hospital Prof. Doutor Fernando Fonseca, IC-1...

Two small plaque variants of Japanese encephalitis virus (JEV), S4P9 and S9P10, were recovered from the wild type of JEV strain KE-093 using plaque purification in combination with the temperature-shift induction technique. Growth patterns of the S4P9 and S9P10 in BHK-21 cells as well as neurovirulence in suckling mice were similar to that of KE-093. An amino acid substitution, lysine for gluta...

We report on high spectral resolution observations of five damped Lyman-α absorbers: zabs = 3.0248 toward Q 0347–383, zabs = 2.1411 and 2.8112 toward Q 0528–250, zabs = 2.6184 toward Q 0913+072, and zabs = 2.5226 toward Q 1213+093. Line velocity profiles and heavy element abundances are discussed. Nitrogen is found to have abundances less than silicon in the systems toward Q 0347−383, Q 0913+07...

In this paper the strength of adhesive joint under tension and bending is discussed on the basis of intensity of singular stress by the application of FEM. A useful method is presented with focusing on the stress at the edge of interface between the adhesive and adherent obtained by FEM. After analyzing the adhesive joint strength with all material combinations, it is found that to improve the ...

1 The Mind/Body Medical Institute, CareGroup and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, U.S.A. 2 Kliniken Essen-Mitte, Department for Internal and Integrative Medicine, 45276 Essen, Germany 3 Neuroscience Research Institute, State University of New York at Old Westbury, NY 11568, U.S.A. 4 The Carter Center Mental Health Program, At...