Myristoylated alanine-rich C-kinase substrate (MARCKS) is a ubiquitously expressed substrate of protein kinase C (PKC) that is involved in reorganization of the actin cytoskeleton. We hypothesized that MARCKS is involved in regulation of fibroblast migration and addressed this hypothesis by utilizing a unique reagent developed in this laboratory, the MANS peptide. The MANS peptide is a myristoy...

We have synthesized core-shell structured 3-methacryloxypropyltrimethoxysilane (MPS) functionalized antimony-doped tin oxide nanoparticles (MANs)-poly(methyl methacrylate-co-butyl acrylate) (PMMA-co-BA, PMB) nanocomposite latex particles via miniemulsion polymerization method. Polymerizable anionic surfactant DNS-86 (allyloxy polyoxyethylene(10) nonyl ammonium sulfate) was first introduced to s...

Allergic asthma is associated with airway epithelial cell mucous metaplasia and mucin hypersecretion, but the consequences of mucin hypersecretion on airway function are unclear. Recently, a peptide derived from the myristoylated alanine-rich C kinase substrate protein NH(2)-terminal sequence (MANS) was shown to inhibit methacholine (MCh)-induced mucin secretion from airway mucous cells by >90%...

β-1,2-mannosylation of Candida albicans glycoconjugates has been investigated through the identification of enzymes involved in the addition of β-1,2-oligomannosides (β-Mans) to phosphopeptidomannan and phospholipomannan. β-1,2-oligomannosides are supposed to have virulence properties that they confer to these glycoconjugates. In a previous study, we showed that cell wall mannoproteins (CWMPs) ...

In a mouse model of neutrophil elastase-induced bronchitis that exhibits goblet cell metaplasia and inflammation, we investigated the effects of intratracheal instillation of the MANS peptide, a peptide identical to the NH(2) terminus of the myristoylated alanine-rich C kinase substrate (MARCKS) on mucin protein airway secretion, inflammation, and airway reactivity. To induce mucus cell metapla...

Malaysia suffers from a chronic shortage of human organs for transplantation. Medical and nursing students (MaNS) are future health professionals and thus their attitude toward organ donation is vital for driving national donation rates. This study investigates MaNS' willingness to donate organs upon death and the factors influencing their willingness. A cross-sectional design was used with a s...

En 2007, Michael D. Reeve a proposé d’identifier le manuscrit Le Mans, Médiathèque Louis-Aragon, 263, un beau témoin de la Naturalis historia Pline l’Ancien datant du XIIe siècle, avec l’exemplaire conservé au Mont Saint-Michel entre milieu siècle – quand il y aurait été apporté et corrigé par célèbre abbé Robert Torigni fin XVIIe ; Patricia Stirnemann l’a en revanche présenté comme codex fait ...

Anemie in bejaardes het verskeie negatiewe gevolge vir gesondheid, algemene welstand en langslewendheid. Bejaardes wat in peri-stedelike woongebiede woon is veral blootgestel aan risikos as gevolg van voedsel en voeding insekuriteit wat verband hou met armoede en dus lei tot ‘n koolhidraatryke dieet laag in yster, folaat en vitamien B12. Hierdie studie ondersoek die voorkoms van anemie en die v...

1Department of Family Medicine and Emergency Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada; 2Centre intégré universitaire de santé et de services sociaux du Saguenay–Lac-Saint-Jean, Chicoutimi, Canada; 3Department of General Practice, University of Angers, L’Université Nantes Angers Le Mans, Angers, France; 4Laboratory of Ergonomics and Epidemiology in Occupational Health, Univ...