This paper is concerned with the first crossing of an order statistic point process through general moving boundaries. Our purpose is to determine exact boundary crossing probabilities in both one and two boundary cases. Simple recursive methods are obtained that exploit an underlying algebraic structure of polynomial type. This structure is a direct consequence of the order statistic property....

Data collected from response adaptive designs are dependent. Traditional statistical methods need to be justified for the use in response adaptive designs. This paper generalizes the Rao’s score test to response adaptive designs and introduces a generalized score statistic. Simulation is conducted to compare the statistical powers of the Wald, the score, the generalized score and the likelihood...

The specification of the skeletal muscle lineage during craniofacial development is dependent on the activity of MYF5 and MYOD, two members of the myogenic regulatory factor family. In the absence of MYF5 or MYOD there is not an overt muscle phenotype, whereas in the double Myf5;MyoD knockout branchiomeric myogenic precursors fail to be specified and skeletal muscle is not formed. The transcrip...

In this paper, the distribution of the likelihood ratio statistic for testing the hypothesis that the covariance matrix of a p-variate normal distribution is circular symmetric has been derived. The distribution is obtained in series form using the inverse Mellin transform and the residue theorem. Percentage points for p=4; 5; 6 and 7 have been computed using distributional results derived in t...

A weighted U -statistic based on a random sample X1, . . . , Xn has the form Un = ∑ 1≤i,j≤n wi−jK(Xi, Xj) where K is fixed symmetric measurable function and the wi are symmetric weights. A large class of statistics can be expressed as weighted U -statistics or variations thereof. This paper establishes the asymptotic normality of Un when the sample observations come from a non-linear time serie...

the effect of lavender aromatherapy program on the pain intensity of patients with aml undergoing chemotherapy     babashahikohanestani f [1] , ahmadi f [2] *, memarian r [3]     received: 30 jan , 2013 accepted: 14 apr , 2013     abstract   background & aims : the painis the most common problem in patients undergoing chemotherapy. nurses have the key role to determine and control signs and sym...

introduction: population-based mortality statistics are derived from the information recorded on death certificates. this information is used for many important purposes, such as development of public health programs and allocation of health care resources. therefore, the accuracy of death certificate data is important. the aim of this study was to evaluate the quality of death certificates rec...