Rheumatoid arthritis (RA) significantly affects quality of life. We recently cloned synoviolin, a RING-type E3 ubiquitin ligase implicated in the endoplasmic reticulum-associated degradation (ERAD) pathway. Synoviolin is highly expressed in rheumatoid synovial cells and may be involved in the pathogenesis of RA. Inhibition of synoviolin activity i...

This study compared the volumetric shrinkage (VS), flexural strength (FS) and flexural modulus (FM) properties of the low-shrinkage resin composite Aelite LS (Bisco) to those of Filtek LS (3M ESPE) and two regular dimethacrylate-based resin composites, the microfilled Heliomolar (Ivoclar Vivadent) and the microhybrid Aelite Universal (Bisco). The composites (n = 5) were placed on the Teflon ped...

background: socioeconomic status (ses) is a major determinant of health inequality in children and adolescents. the aim of this study was to evaluate the association of ses of family and living region with self-rated health (srh) and life satisfaction (ls) among children and adolescents.   methods: this study was a part of the fourth survey of a national surveillance program, which was conducte...

a quantitative structure–activity relationship (qsar) study is suggested for the prediction of biological activity (pic 50 ) of 3, 4-dihydropyrido [3 ,2-d] pyrimidone derivatives as p38 inhibitors. modeling of the biological activities of compounds of interest as a function of molecular structures was established by means of principal component analysis (pca) and least square support vector mac...

conclusions our findings show that, at provincial levels, a complex set of known/unknown influencing factors affect individuals’ assessments of their own health quality. understanding these patterns of srh and ls could be useful for better health policy and more targeted studies in this field. background self-rated health (srh) and life satisfaction (ls) are of increasing interest to medical re...