F or much of the past quarter century, 2 broadly competing scientific views have dominated translational research concerning atherogenesis and atherothrombosis. On one side has been a predominantly lipid-centric view in which lowdensity lipoprotein (LDL) cholesterol, a proven causal factor in atherosclerosis, has been viewed as the major if not sole determinant of disease initiation and progres...

Objective: Coronary heart disease (CAD) is the commonest complication in patients with chronic kidney disease (CKD) under hemodialysis (HD). Coronary risk biomarkers, namely, plasma levels of lipids, apo(lipo)proteins, oxidized (ox)-lowdensity lipoprotein (LDL), and adiponectin were compared between HD patients and age, sex, and body mass index-matched controls. Methods and results: Eighty HD p...

Dyslipidemia, particularly the elevation of lowdensity lipoprotein cholesterol (LDL-C) levels, is the prerequisite for the occurrence and development of plaque-based atherosclerotic cardiovascular disease (ASCVD). LDL particles pass through the vascular endothelium and become lodged within the walls of blood vessels. Oxidative modification of LDL then occurs under the action of extracellular ma...

A ltered concentrations of blood plasma lipoproteins are powerful predictors of coronary heart disease (CHD) and of other manifestations of atherosclerosis. Reduction of elevated lowdensity lipoprotein cholesterol (LDL cholesteroD and concomitant increases in highdensity lipoprotein cholesterol (HDL cholesterol) have been shown to reduce myocardial infarction and death from CHD in people with n...

serum and, while dibutyryl cyclic AMP (dbcAMP) caused a marked stimulation of progesterone production in complete serum, it had only a small effect in LPDS. Lowdensity lipoprotein (LDL) and high-density lipoprotein (HDL) increased basal and dbcAMP-stimulated progesterone production. Cells were 7 times more sensitive to LDL than HDL although the maximum response to both lipoproteins did not diff...

Purpose: To determine objectively measured intensity of physical activity (iPA) and its relationship to high-density lipoprotein cholesterol (HDL-C), lowdensity lipoprotein cholesterol (LDL-C), and the LDL/HDL ratio in women. Methods: Two hundred seventy-two women (40.1 y) wore CSA-MTI model 7164 accelerometers to index intensity and volume of physical activity for 7 d. Blood lipids were measur...

Since 1988, with the release of the National Cholesterol Education Panel (NCEP) Adult Treatment Panel I, lowdensity lipoprotein cholesterol (LDL-C) has been the primary focus of therapy (1). Although the total cholesterol to high-density lipoprotein cholesterol (HDL-C) ratio is a better cardiovascular risk predictor (2), the consensus at the time was that the clinical evidence only supported LD...

DR. DAVIDSON: Cholesteryl ester transfer protein (CETP) has been a target for the management of risk for cardiovascular disease. This effort began a number of years ago when it was noted that this protein transfers cholesteryl ester in exchange for triglyceride from different lipoproteins, specifically apolipoprotein (apo)B-lipoproteins to high-density lipoproteins (HDL). It’s an exchange that ...

Inflammation may contribute to the pathogenesis of atherosclerosis. On the basis of previous reports that human atherosclerotic lesions contain a-defensins, a class of cationic proteins released by activated neutrophils, the study was designed to ask whether defensins modulate the binding and catabolism of lowdensity lipoprotein (LDL) by human vascular cells. The results of the study demonstrat...