introduction: considering high prevalence of epileptic disease and considering that 40 percent of epileptic patients are resistant to drug therapy, it needs more researches to find new therapeutic ways. lfs is among the new methods for epilepsy treatments. one possible mechanism involved in the anticonvulsant effect of lfs is increased adenosine. therefore, in this study the role of adenosine p...

introduction: electrical low-frequency stimulation (lfs) has antiepileptic effect, but the role of different stimulation parameters on this effect has not been determined. in this study the effect of different lfs parameters (intensity, pulse duration and train duration) on piriform-cortex kindled seizures was investigated. methods: seizure was produced in animals using kindling model of epilep...

introduction: previous studies have been shown that low frequency stimulation (lfs) has an inhibitory effect on kindling acquisition. however, the mechanism of this effect has not been completely determined. in the present study, the effect of lfs of the perforant path on seizures induced by rapid perforant path kindling was investigated. methods: animals were kindled by electrical stimulation ...

introduction: low-frequency stimulation (lfs) has a delaying effect on kindled seizures acquisition. in the present study we examined the role of galanin receptors in the inhibitory effects of lfs on kindled seizures induced by electrical stimulation of perforant path. methods: animals were stimulated daily at the ad threshold intensity with a rapid kindling procedure. lfs was applied immediate...

introduction: application of low-frequency stimulation (lfs) is a new method for treatment of drug resistant epileptic patients. previous studies demonstrated that activation of receptors coupled to gi proteins is one of the mechanisms of the anticonvulsant effect of lfs. thus, in this study, alterations in the expression of rgs4 and rgs10 proteins, as negative regulators of gi proteins, were i...

low frequency stimulation (lfs) is a potential alternative therapy for epilepsy. however, it seems that the anticonvulsant effects of lfs depend on its target sites in the brain. thus, the present study was designed to compare the anticonvulsant effects of lfs administered to amygdala, piriform cortex and substantia nigra on amygdala kindling acquisition. in control group, rats were kindled in ...

Background: The interaction between antiepileptic drugs and brain electrical stimulation is a potential therapy to control of seizures in patient with pharmacoresistance to drugs. So, the aim of present study was designed to determine the effect of a sub effective dose of sodium valproate combined with low-frequency electrical stimulation during kindling. Material and Methods: One tripolar ele...

The present study was a protocol for investigation of the effect of acetaminophen (i.p.) on pain induced by electrical stimulation. We used tail shock vocalization (TSV) test for measurement of the pain. In this test, the animals were restrained and stimulated by two electrode implanted on the middle of the animal’s tail. The latency from stimulation of the tail till vocalization of the animal ...

The present study was a protocol for investigation of the effect of acetaminophen (i.p.) on pain induced by electrical stimulation. We used tail shock vocalization (TSV) test for measurement of the pain. In this test, the animals were restrained and stimulated by two electrode implanted on the middle of the animal’s tail. The latency from stimulation of the tail till vocalization of the animal ...