breast cancer is the most common cancer among women in developed countries. the prevalence of the disease is increasing in the world. its annual incidence among iranian women is about 7000 cases. rap1a, a tumor suppressor gene, is located at 1p13.3 and plays an important role in the cellular adhesion pathway and is involved in the pathogenesis of breast cancer. the dock4 gene, which is located ...

Objective(s): Variation in microsatellite sequences that are dispersed in the genome has been linked to a deficiency in cellular mismatch repair system and defects in several genes of this system are involved in carcinogenesis. Our aim in this study was to illustrate microsatellite DNA alteration in esophageal cancer. Materials and Methods: DNA was extracted from formalin fixed paraffin embedde...

INTRODUCTION Loss of heterozygosity (LOH) is frequently observed in urinary bladder neoplasms. In the reported study, an attempt was undertaken to determine the loss of heterozygosity of TP53(17p13), RB1(13q14), CDKN2A/ ARF(9p21) genes in DNA from neoplastic tissue, collected from patients with diagnosed urinary bladder carcinoma, and to compare the results with those of LOH evaluation in DNA i...

Loss of heterozygosity (LOH) occurs in a variety of diploid organisms after chemical mutagenesis and was observed in the vegetable pathogen Phytophthora capsici after N-ethyl-nitrosourea (ENU) mutagenesis at three loci during reverse genetic screening. Our objectives were to determine (i) the frequency of LOH among mutants, (ii) the directionality of the LOH events and (iii) the length of the g...

Breast tumors in (FVB × BALB-NeuT) F1 mice have characteristic loss of chromosome 4 and sporadic loss or gain of other chromosomes. We employed the Illumina GoldenGate genotyping platform to quantitate loss of heterozygosity (LOH) across the genome of primary tumors, revealing strong biases favoring chromosome 4 alleles from the FVB parent. While allelic bias was not observed on other chromosom...

objective(s): variation in microsatellite sequences that are dispersed in the genome has been linked to a deficiency in cellular mismatch repair system and defects in several genes of this system are involved in carcinogenesis. our aim in this study was to illustrate microsatellite dna alteration in esophageal cancer. materials and methods: dna was extracted from formalin fixed paraffin embedde...