نتایج جستجو برای: log (predicted psa)

تعداد نتایج: 283933  

2011
R. Shawahna NU. Rahman

BACKGROUND AND THE PURPOSE OF THE STUDY Partition coefficients (log D and log P) and molecular surface area (PSA) are potential predictors of the intestinal permeability of drugs. The aim of this investigation was to evaluate and compare these intestinal permeability indicators. METHODS Aqueous solubility data were obtained from literature or calculated using ACD/Labs and ALOGPS. Permeability...

Akula Pranitha PK Lakshmi

The aim of the present study was to investigate the relationship between the polar surface area and other molecular properties of the model drugs and their transdermal permeability across the rat skin. Few model drugs which are weakly acidic (ibuprofen, aceclofenac and glipizide) and weakly basic (olanzapine, telmisartan and sildenafil citrate) were selected for the study based on Polar surface...

Journal: :iranian journal of pharmaceutical sciences 0
akula pranitha department of pharmaceutics, g pulla reddy college of pharmacy, mehdipatnam, hyderabad, telangana, india. pk lakshmi department of pharmaceutics, g pulla reddy college of pharmacy, mehdipatnam, hyderabad, telangana, india.

the aim of the present study was to investigate the relationship between the polar surface area and other molecular properties of the model drugs and their transdermal permeability across the rat skin. few model drugs which are weakly acidic (ibuprofen, aceclofenac and glipizide) and weakly basic (olanzapine, telmisartan and sildenafil citrate) were selected for the study based on polar surface...

2011
Ja Hyeon Ku Kyung Chul Moon Cheol Kwak Hyeon Hoe Kim

PURPOSE The purpose of this study was to evaluate whether predicted tumor volume could predict pathologic stage in patients undergoing radical prostatectomy. MATERIALS AND METHODS The clinical and pathologic data of 236 patients who underwent a 12-core needle biopsy followed by radical prostatectomy were obtained from our database and reviewed retrospectively. RESULTS Observed tumor volume ...

2014
Atsushi Tomioka Nobumichi Tanaka Motokiyo Yoshikawa Makito Miyake Satoshi Anai Yoshitomo Chihara Eijiro Okajima Akihide Hirayama Yoshihiko Hirao Kiyohide Fujimoto

BACKGROUND Primary androgen deprivation therapy (PADT) is the most effective systemic therapy for patients with metastatic prostate cancer. Nevertheless, once PSA progression develops, the prognosis is serious and mortal. We sought to identify factors that predicted the prognosis in a series of patients with metastatic prostate cancer. METHODS Two-hundred eighty-six metastatic prostate cancer...

Journal: :Frontiers in Immunology 2023

Background Some retrospective studies reported that psoriasis (PsO) and psoriatic arthritis (PsA) may have been associated with an elevated risk of skin cancer. The causal associations among them remain unclear. Objectives To evaluate the association both PsO PsA, Methods We performed large-scale two-sample Multivariate Mendelian randomization analyses to examine whether there is a relationship...

Journal: :Cancer prevention research 2015
Bernard G Cipolla Eric Mandron Jean Marc Lefort Yves Coadou Emmanuel Della Negra Luc Corbel Ronan Le Scodan Abdel Rahmene Azzouzi Nicolas Mottet

Increases in serum levels of prostate-specific antigen (PSA) occur commonly in prostate cancer after radical prostatectomy and are designated "biochemical recurrence." Because the phytochemical sulforaphane has been studied extensively as an anticancer agent, we performed a double-blinded, randomized, placebo-controlled multicenter trial with sulforaphane in 78 patients (mean age, 69 ± 6 years)...

Journal: :Asian journal of andrology 2011
Ja Hyeon Ku Kyung Chul Moon Sung Yong Cho Cheol Kwak Hyeon Hoe Kim

The aim of this study was to investigate the significance of serum prostate-specific antigen (PSA) value adjusted for total tumor volume (PSA/tumor volume) and serum PSA value adjusted for non-cancerous prostate tissue volume (NCPV) (PSA/NCPV) as a predictor of pathological findings and clinical outcome after radical prostatectomy. Clinical and pathological data of 407 patients (median age: 66....

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1999
R T Vollmer P W Kantoff N A Dawson N J Vogelzang

Previously, we have shown that serial measurements of prostate-specific antigen (PSA) in hormone-refractory prostate cancer (HRPC) can be used to calculate an average relative velocity (rva) of PSA. Together, the level of PSA and the rva formed a two-variable model for survival time that worked at any time during the course of HRPC. Here, we have added serial measurements of hemoglobin and weig...

2012
Matteo Nicola Dario Di Minno Rosario Peluso Salvatore Iervolino Roberta Lupoli Anna Russolillo Giovanni Tarantino Raffaele Scarpa

INTRODUCTION We prospectively evaluated whether hepatic steatosis (HS) and the presence of carotid plaques (CPs) impacts on achieving minimal disease activity (MDA) in psoriatic arthritis (PsA) patients starting tumor necrosis factor (TNF)-α blockers treatment. METHODS Before starting treatment with TNF-α blockers, consecutive PsA subjects with an active disease were evaluated for the presenc...

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