objective: the purpose of this study was to evaluate the effect of adjunctive topiramate in treating acute mania. methods: in this study which was a double-blinded randomized clinical trial, 46 bipolar patients in manic episode, were treated with lithium carbonate and topiramate versus lithium carbonate and placebo and treatment responses were assessed by young mania rating scale (ymrs) weekly....

OBJECTIVE The purpose of this study was to evaluate the effect of adjunctive topiramate in treating acute mania. METHODS In this study which was a double-blinded randomized clinical trial, 46 bipolar patients in manic episode, were treated with lithium carbonate and topiramate versus lithium carbonate and placebo and treatment responses were assessed by Young Mania Rating Scale (YMRS) weekly....

BACKGROUND Conventional meta-analyses have shown inconsistent results for efficacy of pharmacological treatments for acute mania. We did a multiple-treatments meta-analysis, which accounted for both direct and indirect comparisons, to assess the effects of all antimanic drugs. METHODS We systematically reviewed 68 randomised controlled trials (16,073 participants) from Jan 1, 1980, to Nov 25,...

2004;6(4):333-7. Dear Editor, Topiramate is a novel anticonvulsant that has been used for bipolar disorder. However, no clear evidence of efficacy was found in clinical trials. More recently, topiramate has been used for the management of weight gain associated with the use of mood stabilizer and atypical antipsychotics. There are only two reported cases of treatment emergent affective switch (...

the effect of neuroloptics. carbamacepine and hensmliacepines in treatment of 8.3 patients with acute mania was studied. according to drug types. patients were divided into 5 groups: 1) lithium combined with ilubupridol. 2) lithium combined with one plxenoshiacine 3) lithium combined with two phenothiazines. 4) lithium combined with cubumazepine and 5) lithium combined with benzxliazepines no s...

Results In a recent meta-analysis, efficacy for mania compared to placebo was demonstrated for all studied antipsychotics, lithium and selected antiepileptic medications, such as carbamazepine and valproic acid. Conversely, lamotrigine and topiramate were not superior to placebo. The pooled effect sizes of the agents separating from placebo ranged from 0.23 (small) to 0.66 (moderate), with over...

The disorder is frequently unrecognized, misdiagnosed, and not optimally managed. Moreover, no agent has been specifically developed on the basis of an understanding of the pathophysiology of the illness or mechanism of action of effective treatments. The current gold standard treatment for BP is lithium, whose mood-stabilizing effects are believed to occur via distinct cellular signaling pathw...