This study was designed to investigate the protective effect and possible molecular mechanism of liquiritin on oxybuprocaine-induced apoptosis of human corneal endothelial cells (HCECs). In this study, the effect of oxybuprocaine on the proliferation of HCEC-12 was detected using cell counting kit-8 (CCK-8). The inductive effect of oxybuprocaine on HCEC-12 apoptosis and protective effect of liq...

Background and objectives: Rutin, quercetin and liquiritin are polyphenol flavonoids which have shown anti-inflammatory, antihepatotoxic, antiulcer, antiallergic, antidiabetic, antiviral and antioxidant activities. They are found in many herbal plants, one of them is Cocculus hirsutus. The objective of this research was to develop and validate a new, accurate, precise and economic HPTLC method ...

Shaoyao-Gancao (Paeoniae Radix Alba and Glycyrrhizae Radix et Rhizoma) is a traditional Chinese drug pair widely used in decoctions for relieving pains, especially abdominal pain. We aimed to determine the intestinal absorption and interaction of three active compounds (glycyrrhizic acid, liquiritin, and paeoniflorin) in this drug pair. We investigated the transport of these compounds across in...

Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influence of glycyrrhiza, three glycyrrhiza constituents (glycyrrhizin, liquiritin, and liquiritin apioside), and eight antibiotics on the purgative action of DKT, rhubarb, or sennoside A, a constituent ...

Background. Shaoyao-Gancao Decoction (SGD), a well-known traditional Chinese medicine prescription, has been widely used to treat adenomyosis, dysmenorrhea, abdominal pain, and inflammation in Asia. However, the mechanism underlying the effectiveness of SGD in the treatment of adenomyosis still remains elusive. The present study aimed to investigate the bioactivity of SGD and its underlying mol...

Background and objectives: Rutin, quercetin and liquiritin arepolyphenol flavonoids which have shown anti-inflammatory, antihepatotoxic, antiulcer, antiallergic, antidiabetic, antiviral and antioxidant activities. They are found in many herbal plants, one of them is Cocculus hirsutus.  The objective of this research was to develop and validate a new, accurate, precise and economic HPTL...

BACKGROUND Compatibility of Radix Aconiti Carmichaeli and Liquorice is known to treat heart diseases such as heart failure and cardiac arrhythmias. This work answers the question that whether the active components (Aconitine, Liquiritin and Glycyrrhetinic Acid) of Radix Aconiti Carmichaeli and Liquorice could result in regulating intracellular calcium homeostasis and calcium cycling, and thereb...

Liquiritin, isoliquiritin and isoliquirigenin are the active polyphenols present in Glycyrrhiza uralensis which has been used for the treatment of cancer and its complications. The present study was conducted to evaluate the cytotoxicity and antitumor activity of liquiritin, isoliquiritin and isoliquirigenin on human non-small lung cancer cells including apoptosis-induction, inhibition of apopt...

background and objectives: rutin, quercetin and liquiritin arepolyphenol flavonoids which have shown anti-inflammatory, antihepatotoxic, antiulcer, antiallergic, antidiabetic, antiviral and antioxidant activities. they are found in many herbal plants, one of them is cocculus hirsutus.  the objective of this research was to develop and validate a new, accurate, precise and economic hptlc method ...

We describe here a method using HPLC for the simultaneous determination of albiflorin, paeoniflorin, glycyrrhizin and six flavanone glycosides (liquiritin, liquiritin apioside, naringin, neohesperidin, hesperidin and narirutin) in the Kampo medicines, Shigyaku-san and Haino-san. All nine components were separated in less than 40 min by linear gradient elution using a mobile phase containing aqu...