Objective: to present corneal collagen corsslinking techniques. Corneal collagen cross-linking (CXL) is a procedure used to slow down or arrest the progression of keratoconus in order to avoid or, at least delay the necessity of keratoplasty. CXL means photopolimerisation of the stromal fibrillar tissue, in order to increase their stiffness and resistance to the corneal ectasia. CXL is a proces...

PURPOSE Corneal cross-linking (CXL) is a treatment for keratoconus that eliminates the need for keratoplasty in most patients. However, its molecular mechanisms remain under study. Advanced glycation end products (AGEs) have been suggested by many studies as the causative strengthening agent during CXL, though no studies to date have directly tested this hypothesis. METHODS Corneas of young r...

PURPOSE The purpose of this study was to use noncontact optical coherence elastography (OCE) to evaluate and compare changes in biomechanical properties that occurred in rabbit cornea in situ after corneal collagen cross-linking by either of two techniques: ultraviolet-A (UV-A)/riboflavin or rose-Bengal/green light. METHODS Low-amplitude (≤10 μm) elastic waves were induced in mature rabbit co...

purpose: to evaluate the effectiveness of corneal collagen cross-linking with uv-a and riboflavin (cxl) for treatment of refractory herpes simplex virus necrotizing keratitis. case reports: two patients with a diagnosis of hsv necrotizing stromal keratitis referred to khalili hospital eye emergency room and who were resistant to conventional treatment underwent cxl. response to treatment was ev...

241 Wollensak et al reported the first application of corneal cross‐linking (CXL) for the treatment of keratoconus in 2003.[1] Thereafter, many articles were published regarding the efficacy of CXL to halt the progression of keratoconus. Long‐term studies have shown its success rate ranging from 78% to 100%.[2,3] Two studies evaluated the effect of CXL on decreasing the number for keratoplasty ...

PURPOSE To compare biomechanical effect, riboflavin penetration and distribution in transepithelial corneal collagen cross-linking with iontophoresis (I-CXL), with standard cross linking (S-CXL) and current transepithelial protocol (TE-CXL). MATERIALS AND METHODS The study was divided into two different sections, considering, respectively, rabbit and human cadaver corneas. In both sections co...

PURPOSE Evaluating the clinical results of trans-epithelial collagen cross-linking (CXL) and standard CXL in patients with progressive keratoconus. METHODS This prospective study comprised 20 eyes of 20 patients with progressive keratoconus. Ten eyes were treated by standard CXL and ten by trans-epithelial cross-linking (TE-CXL, epithelium on) with 1 year of follow-up. All patients underwent ...

INTRODUCTION The purpose of this study was to evaluate the efficacy and safety of iontophoretic collagen cross-linking (I-CXL) compared to epithelium-off standard collagen cross-linking (CXL) in treating the early stages of progressive keratoconus. METHODS This retrospective cohort study at Oftaprof Clinic, Iasi, Romania included 40 eyes of 40 patients with progressive keratoconus stage I acc...

IMPORTANCE We describe and evaluate a complementary method to indirectly quantify the treatment effect of corneal cross-linking (CXL). Additional methods to indirectly quantify the treatment effect of CXL are needed. OBJECTIVE To assess the spatial distribution and the time course of the increased corneal densitometry (corneal light backscatter) seen after CXL with riboflavin and UV-A irradia...