objective(s): umbilical cord blood-derived mesenchymal stromal cells (ucb-mscs) are ideally suited for use in various cell-based therapies. we investigated a novel induction protocol (nip) to improve the neuronal differentiation of human ucb-mscs under appropriate conditions. materials and methods: this experimental study was performed in iranian blood transfusion organization (ibto), tehran, i...

background: pattern recognition receptors (prrs) are the main sensors of pathogen and danger signals in innate immunity of which toll like receptors (tlrs) are the most studied ones. the contribution of prrs in cerebral inflammation induced by microbial infection, tissue damage and cancer has not extensively been addressed so far. glioma is the most common tumor of the central nervous system an...

conclusions our results suggest that human exposure to mcpyv occurs throughout life. the mcpyv antibody levels remained high among older adults in our population, consistent with reports from other populations. patients and methods in this cross-sectional study, we collected 440 serum samples from healthy individuals 2 to 78 years of age who visited the pasteur institute’s clinic in tehran, ira...

cell replacement therapy has provided the basis for future clinical applications to treat central nervous system injuries fallowing by car accidents. induced functional neurons are an option for replacing the lost neurons. the ability to monitor changes in membrane potential is a useful tool for studying neuronal function, but there are only limited options available at present. here, investiga...

host genetic factors play a central role in determining the clinical phenotype of human diseases. association between two polymorphic loci in human genome, human leukocyte antigen (hla) and killer cell immunoglobulin-like receptors (kirs), and genetically complex infectious disease, particularly those of viral etiology, have been historically elusive. hence, defining the influence of genetic di...

conclusions taken together, the combination of chemical and growth factors in the two-step induction protocol may improve the efficiency of msc differentiation into neural progenitor cells, and may be a new method for the easy and fast application of mscs in regenerative medicine in the future. results the results of real-time pcr showed that the expression of the gfap, mbp, and map-2 genes aft...

background: cryptorchidism is a common malformation in neonates; surgery or medical treatments are applied during childhood. untreated cryptorchid testes are in the risk of intratubular germ cell neoplasia (igcn) and consequently invasive testicular tumors which could be shown by immunohistochemistry staining for placental like acid phosphatase (plap) marker. objective: we designed this study t...

background:   objective: this study presents an economical and simple co-culture system for pluripotent stem cells generation from neonatal mouse testis   materials and methods: isolated testicular cells were cultured in dmem/f12. characteristics of the isolated cells and obtained es-like cell were immune-cytochemically confirmed by examining the presence of plzf, vimentin, oct4 and nanog prote...

the sex cord-like variant of endometrioid carcinoma is a rare subtype with a close histological resemblance to the sex cord-stromal tumor of the ovaries, in particular the sertoli cell tumor. however, very few cases of the granulosa cell tumor-like variant have been reported since it is commonly misdiagnosed as a granulose cell tumor. immunohistochemistry is useful in the diagnosis of these tum...