mrs. heidari, 53 developed ventricular fibrillation and cardiopulmonary arrest after receiving 15 ml lidocaine 2% for local anesthesia at the dr. shariati hospital cathlab. there was no identified risk factor for her arrest preoperatively. she had a history of exertional chest pain for about 5 years and an electrocardiogram showed only inverted t-waves at the time of angiography. the case is re...

BACKGROUND Tumescent lidocaine anesthesia consists of subcutaneous injection of relatively large volumes (up to 4 L or more) of dilute lidocaine (≤1 g/L) and epinephrine (≤1 mg/L). Although tumescent lidocaine anesthesia is used for an increasing variety of surgical procedures, the maximum safe dosage is unknown. Our primary aim in this study was to measure serum lidocaine concentrations after ...

For more than 50 years lidocaine has been used to treat ventricular arrhythmias. Neurologic dysfunction, manifested as a stroke, occurred acutely in an 87-year-old woman after she had been administered repeated doses of lidocaine, a lidocaine infusion, then an intravenous amiodarone infusion for ventricular tachycardia. This was ultimately diagnosed as lidocaine toxicity with a serum lidocaine ...

For the past 50 years, local anesthetics such as lidocaine have been commonly used in various clinical settings. Its use is not just limited to anesthesia and surgery but is also frequently utilized in internal medicine and in primary care setting for bedside procedures. Despite its widespread use, most physicians are not familiar with the life-threatening manifestations of lidocaine toxicity a...

Evidence from both clinical studies and animal models suggests that the local anesthetic, lidocaine, is neurotoxic. However, the mechanism of lidocaine-induced toxicity is unknown. To test the hypothesis that toxicity results from a direct action of lidocaine on sensory neurons we performed in vitro histological, electrophysiological and fluorometrical experiments on isolated dorsal root gangli...

The serum and urine levels of lidocaine and two active dealkylated metabolites, monoethylglycinexylidide (MEGX) and glycinexylidide (GX), were determined by HPLC in 33 cardiac patients receiving lidocaine for more than 1 day. Clinical assessment of nervous system toxicity was carried out at the time of blood drawing. The ratios in serum of MEGX to lidocaine and of GX to lidocaine were 0.36 +/- ...

ObjectiveTo evaluate the total toxic dose of lidocaine and serum lidocaine concentrations resulting in clinical signs of toxicity in chickens. DesignExperimental study AnimalsEight healthy, female, 55-week-old chickens (Lohman breed) weighing 1.45 ± 0.17 kg (mean ± SD) ProcedureA loading dose of 2% lidocaine (4 mg/kg) was administered IV, followed by a constant-rate infusion at a dose of 8 mg/k...

Objective- To evaluate the total toxic dose of lidocaine and serum lidocaine concentrations resulting in clinical signs of toxicity in chickens. Design- Experimental study Animals- Eight healthy, female, 55-week-old chickens (Lohman breed) weighing 1.45 ± 0.17 kg (mean ± SD) Procedure- A loading dose of 2% lidocaine (4 mg/kg) was administered IV, followed by a constant-rate infusion at a dose o...