Local analysis of dental calcified tissues plays important role in medicine, toxicology, environmental science, paleontology and anthropology. In these fields of action a bulk analysis of a mineralized material from a defined and welllocalized volume belongs to a marginal stream. On the other hand, spatially resolved analyses of calcified tissues as teeth or bones without any previous decomposi...

This paper introduces the first use of laser-generated proton beams as diagnostic for materials of interest in the domain of Cultural Heritage. Using laser-accelerated protons, as generated by interaction of a high-power short-pulse laser with a solid target, we can produce proton-induced X-ray emission spectroscopies (PIXE). By correctly tuning the proton flux on the sample, we are able to per...

Fluorine (F) and strontium (Sr) are key elements in the de- and remineralization of teeth. To quantitatively analyze the distribution of F and Sr, micro-particle-induced gamma/X-ray emission (PIGE/PIXE) technique was used. The cavities were prepared and filled with the fluoride- and Sr-containing restorative materials (FSCMs) in extracted human molars. The single-section enamel specimens were p...

OBJECTIVE Therapeutic anticoagulation is widely used, but limitations in efficacy and bleeding complications cause an ongoing search for new agents. However, with new agents developed it seems to be an inherent problem that increased efficiency is accompanied by an increase in bleeding complications. We investigate whether targeting of anticoagulants to activated platelets provides a means to o...

PIXE (Proton Induced X-ray Emission) is a well-known method for elemental analyses of specimens in applied studies. In this paper, we report results of an application of PIXE in trace-element analysis of normal and vitrified carnations in vitro culture. Experiments were performed to study the vitrification in connection with the trace elements in carnation tissues. About two hundred PIXE spectr...

We optimized proton-induced X-ray emission (PIXE) for tissue analysis in a toxicity-disposition study. We used cultured rabbit renal slices as the biological system to demonstrate the use of PIXE analysis. The renal slices were exposed to HgCl2, CdCl2, K2Cr2O7, or NaAsO2 alone or in a mixture. The PIXE analysis provides information on concentrations of elements above atomic number 11, and it is...

BACKGROUND Pulmonary alveolar proteinosis (PAP) is a rare disease occurred by idiopathic (autoimmune) or secondary to particle inhalation. The in-air microparticle induced X-ray emission (in-air micro-PIXE) system performs elemental analysis of materials by irradiation with a proton microbeam, and allows visualization of the spatial distribution and quantitation of various elements with very lo...

Subtle variations in ink color and paper of postage stamps can affect their value and desirability to collectors and investors. Protoninduced Xray emission spectrometry (PIXE) is a generally nondestructive forensic analysis tool that reveals the concentrations of chemical elements in a sample. PIXE has been used for more than 30 years, sometimes in conjunction with other analytical methods, to ...