objective(s) leishmania can lead to a broad spectrum of diseases, collectively known as leishmaniasis. the a2 gene/ protein family could be one of the most eligible candidate factors of virulence in visceral leishmaniasis (vl). the previous results confirmed that in leishmania infantum, several a2 proteins are abundantly expressed by the amastigote, but not the promastigote stage. as there are ...

leishmaniasis is caused by parasitic protozoa of the genus leishmania. cutaneous leishmaniasis (cl) is a complex disease with wide spectrum of clinical manifestations. in order to identify leishmania species causing cl in isfahan by a definite molecular technique (pcr method), this study was undertaken over 2010- 2011. 124 patients with suspicious lesion of leishmaniasis and positive direct sme...

Three species of L. tropica, L. major and L. infantum are known as main causal agents of leishmaniasis have been reported in Iran. Since cutaneous leishmaniasis (CL) is endemic in North East of Iran, in the present work, 50 Leishmania positive isolates from human cases in Mashhad (Center of Razavi province, North East of Iran), were genotyped by means of polymerase chain reaction-restriction f...

background: zoonotic cutaneous leishmaniasis (zcl) is an expanding disease and public health problem in iran. in the current study, natural leishmania infection rate and seasonal fluctuation of the infection in rhombomys opimus population of a hyperendemic focus of zcl in iran was investigated. methods:   the study was conducted from october 2006 to october 2008 in esfahan province, central par...

three species of l. tropica, l. major and l. infantum are known as main causal agents of leishmaniasis have been reported in iran. since cutaneous leishmaniasis (cl) is endemic in north east of iran, in the present work, 50 leishmania positive isolates from human cases in mashhad (center of razavi province, north east of iran), were genotyped by means of polymerase chain reaction-restriction fr...

cutaneous leishmaniasis is one of the most important parasitic diseases, which are endemic in different parts of iran.   leishmania major and l. tropica are the primary causative agents of this disease. the aim of the present study was to detect the multiple forms of l. major in lung. ppromastigotes of l. major at stationary phase were injected to balb/c mice. after 60 days, the different forms...

background: leishmania major is an intracellular parasite transmitted through the bite of the female phlebotomine sand flies. leishmania major is able to escape the host immune defense and survive within macrophages. modulation of the nf-κb (nuclear factor-kappa b) activation and suppression of the pro-inflammatory cytokines by l. major are the main evasion mechanisms that remain to be explored...

background : leishmaniasis is an important public health disease in many developing countries as well in iran. the main objective of this study was to investigate on leishmania infection of wild caught sand flies in an endemic focus of disease in esfarayen district, north east of iran. methods : sand flies were collected by sticky papers and mounted in a drop of puri’s medium for species identi...

background cutaneous leishmaniasis with zoonotic and anthroponotic forms is an endemic disease and a health problem in our country. identification of parasite species and the type of disease is very important for treatment of disease as well as planning the control program. this study was carried out to identify the parasite species causing cutaneous leishmaniasis by nested pcr in poledokhtar d...