fab (french – american- british) group determined a diagnostic classification for leukemia's. but in spite of some reports on different clinical findings and prognosis of hmc and lgl there is no place for hand- mirror cell leukemia and lgl leukemia in this classification. on the other hand, there are different ideas about causes of hand mirror cell and about different changes of large granlar l...

Considering the recent interest in large granular lymphocyte (LGL) proliferation and the frequent association of severe granulopenia (“T-y neutropenia”) with T-LGL leukemia leading to intractable and often fatal infections, we wish to describe a case of T-LGL leukemia with absolute agranulocytosis which showed an excellent, rapid, and sustained response to nontoxic doses of cyclosporine after f...

Considering the recent interest in large granular lymphocyte (LGL) proliferation and the frequent association of severe granulopenia (“T-y neutropenia”) with T-LGL leukemia leading to intractable and often fatal infections, we wish to describe a case of T-LGL leukemia with absolute agranulocytosis which showed an excellent, rapid, and sustained response to nontoxic doses of cyclosporine after f...

Triggering of large granular lymphocyte (LGL) Fc receptor with a specific monoclonal antibody (AB8.28) linked to an insoluble matrix induces cell activation, as witnessed by expression of HLA class II (DR and DQ) molecules and interleukin 2 receptor. Moreover, this event is accompanied by a concomitant release of platelet-activating factor by LGL. We conclude that the Fc receptor molecule ident...

Ten patients with large granular lymphocyte (LGL) leukemia were studied for rearrangement and expression of T cell receptor (TCR) genes. Eight patients with CD3+ LGL proliferation had unique TCR beta-gene rearrangements, supporting a clonal process. Each of five patients studied with CD3+ disease had evidence for expression of full-length TCR alpha-, beta-, and gamma-gene transcripts. In contra...

Large granular lymphocyte (LGL) leukemia is a chronic clonal lymphoproliferative disorder. Here, a T-LGL leukemia patient developed NK-LGL leukemia with residual leukemic T-LGL. TCRVβ usage and CDR3 sequence drifts were observed with disease progression. A STAT3 S614R mutation was identified in NK but not T-cells in the mixed leukemic stage. Multiple, non-dominant T-cell clones with distinct ST...

Large granular lymphosarcaoma / leukemia is a neoplastic disease of lymphocytes that contain intracytoplasmic azurophilic granules. Large granular lymphocytes (LGL) can be found in the blood of healthy domestic species and usually constitute 10% or less of the total circulating lymphocyte pool.2,7 Large granular lymphocytes have lymphocyte morphology, possessing a round or bean-shaped nucleus, ...

Hemophagocytic syndrome (HPS) usually presents as a complication of T/NK cell lymphoma. However, γδ-T large granular lymphocyte leukemia (LGL) associated HPS was rarely reported. Herein, we reported a case of γδ-T LGL associated HPS. A previously healthy 21-year-old Chinese man was admitted with high fever, severe pancytopenia and liver dysfunction. He developed disseminated intravascular coagg...

T-cell large granular lymphocyte (T-LGL) leukemia represents a clonal proliferation of cytotoxic T-cells which etiology has not been entirely elucidated. However, CD4(+), CD4(-), CD8(-), CD4(+), CD8(+) cases have been described. The disease is usually characterized by cytopenias and a modest lymphocytosis. The majority of patients with T-LGL leukemia remains asymptomatic for a long period and w...