نتایج جستجو برای: lactamases.

تعداد نتایج: 4367  

Journal: :Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2012
Po-Lin Chen Wen-Chien Ko Chi-Jung Wu

Aeromonas species, aquatic Gram-negative bacilli, distributed globally and ubiquitously in the natural environment, may be implicated in a variety of human diseases. They can produce various β-lactamases which confer resistance to a broad spectrum of β-lactams, and therefore in vitro susceptibility testing must be used to guide antimicrobial therapy. However, conventional in vitro susceptibilit...

2013
Faridoon Nazar Ul Islam

The production of metallo-β-lactamases is the most important strategy by which pathogenic bacteria become resistant to currently known β-lactam antibiotics. The emergence of these enzymes is particularly concerning for the future treatment of bacterial infections. There are no clinically available drugs capable of inhibiting any of the metallo-β-lactamases, so there is an urgent need to find su...

Journal: :Indian Journal of Animal Research 2022

Background: Escherichia coli is one of the intestinal microbiota in wildlife as domestic animals and humans. The prevalent serogroups, pathogenic strains like STEC, EPEC antimicrobial resistance less frequently studied captive India. present study was aimed to prevalence resistant E. from wild a zoo Kolkata, Methods: This done during March 2019 June for faecal samples birds mammals. pathotypes ...

Journal: :Antimicrobial agents and chemotherapy 2012
Ana Fernández Astrid Pérez Juan A Ayala Susana Mallo Soraya Rumbo-Feal Maria Tomás Margarita Poza Germán Bou

β-Lactamases and penicillin-binding proteins (PBPs) have evolved from a common ancestor. β-Lactamases are enzymes that degrade β-lactam antibiotics, whereas PBPs are involved in the synthesis and processing of peptidoglycan, which forms an elastic network in the bacterial cell wall. This study analyzed the interaction between β-lactamases and peptidoglycan and the impact on fitness and biofilm ...

2011
Sara R. Schlesinger Mieke J. Lahousse Taylor O. Foster Sung-Kun Kim

An evolution of antibiotic-resistant bacteria has resulted in the need for new antibiotics. β-Lactam based drugs are the most predominantly prescribed antibiotics to combat bacterial infections; however, production of β-lactamases, which catalyze the hydrolysis of the β-lactam bond of this class of antibiotics, by pathogenic bacteria such as Bacillus cereus, are rendering them useless. Some inh...

Journal: :Journal of general microbiology 1990
M Forsman B Häggström L Lindgren B Jaurin

Genes encoding extracellular beta-lactamases of Streptomyces badius, Streptomyces cacaoi, Streptomyces fradiae and Streptomyces lavendulae were cloned and mapped in Streptomyces lividans. DNA sequence analysis of the beta-lactamase genes revealed a high overall G + C content, ranging from 71 to 75 mol%, with a G + C content of 95 mol% at the third position of the codons for all four genes. The ...

2002
Septicemia B. Subitha B. Senthil selvan

The most common causes of death in neonatal period is infection (32%) followed by birth asphyxia (29%) and prematurity (24%).Neonatal infections currently cause 1.6 million deaths in developing countries (Choudhury et al., 2007). Multidrug resistant Gram negative bacilli belonging to the family Enterobacteriaceae have been increasingly responsible for infections among the neonates admitted to t...

Journal: :Antibiotics 2014
Nuno T Antunes Jed F Fisher

The Class D β-lactamases have emerged as a prominent resistance mechanism against β-lactam antibiotics that previously had efficacy against infections caused by pathogenic bacteria, especially by Acinetobacter baumannii and the Enterobacteriaceae. The phenotypic and structural characteristics of these enzymes correlate to activities that are classified either as a narrow spectrum, an extended s...

Journal: :Antimicrobial agents and chemotherapy 2016
Sushmita D Lahiri Richard A Alm

Ceftazidime-avibactam has activity against Pseudomonas aeruginosa and Enterobacteriaceae expressing numerous class A and class C β-lactamases, although the ability to inhibit many minor enzyme variants has not been established. Novel VEB class A β-lactamases were identified during characterization of surveillance isolates. The cloned novel VEB β-lactamases possessed an extended-spectrum β-lacta...

Journal: :Antimicrobial agents and chemotherapy 1994
D J Payne R Cramp D J Winstanley D J Knowles

Clavulanic acid, sulbactam, and tazobactam are inhibitors of a variety of plasmid-mediated beta-lactamases. However, inhibition data for these three inhibitors with a wide range of different plasmid-mediated beta-lactamases have not yet been compared under the same experimental conditions. A number of groups have inferred that clavulanic acid inhibits extended-spectrum TEM and SHV beta-lactamas...

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