Rheumatoid arthritis (RA) significantly affects quality of life. We recently cloned synoviolin, a RING-type E3 ubiquitin ligase implicated in the endoplasmic reticulum-associated degradation (ERAD) pathway. Synoviolin is highly expressed in rheumatoid synovial cells and may be involved in the pathogenesis of RA. Inhibition of synoviolin activity i...

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Drs. Blanco and Husain are from Columbia University Medical Center, New York, New York. Dr. Blanco also is from Douglaston Dermatology, New York. Ms. Lal is from New York Institute of Technology College of Osteopathic Medicine, Old Westbury. The authors report no conflict of interest. Correspondence: Fiona P. Blanco, MD, Douglaston Dermatology, 6040 Marathon Pkwy, Douglaston, NY 11362 (fionabla...

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An insect grwoth regulator (IGR), Thompson-Hayward TH 6040 (N-(4-chlorophenyl)-N'-(2,6-difluorobenzoyl)urea), incorporated in the feed of rhinoceroses at rates of 1 and 0.1 mg/kg inhibited development of Musca domestica L. and Stomoxys calcitrans (L.) in the feces.