background: meningioma is among the most common slow growing central nervous neoplasms, which recurs locally despite the benign histologic features. the aim of this study was to evaluate osteopontin and ki67 expressions in different histologic grades of meningioma in a group of iranian people. methods: in this cross-sectional study, first, the paraffin blocks with the definite pathological diag...

biomolecular behavior of tumor cells has become attractive to investigators. p53 as an oncosuppresor gene has been core of various studies and ki67 is a nuclear protein involved in proliferation process. stopping of onco-suppressor function theoretically allows proliferative system to get out of any control. in this case-control study we evaluated 50 patients with non small cell lung cancer, co...

background :cell proliferation is one of the most critical factors in metastasis and prognosis of the malignant tumors.recent investigations show that the eosinophil granolosytes have an important role in developing of malignant tumors. the relation between cell proliferation and eosinophilic infiltration in oral squamous cell carcinoma (oscs) with prognosis is unclear.the aim of this study was...

Background: Meningioma is among the most common slow growing central nervous neoplasms, which recurs locally despite the benign histologic features. The aim of this study was to evaluate osteopontin and ki67 expressions in different histologic grades of meningioma in a group of Iranian people. Methods: In this cross-sectional study, first, the paraffin blocks with the definite pathological dia...

  Background :Cell proliferation is one of the most critical factors in metastasis and prognosis of the malignant tumors.Recent investigations show that the eosinophil granolosytes have an important role in developing of malignant tumors. The relation between cell proliferation and eosinophilic infiltration in oral squamous cell carcinoma (OSCS) with prognosis is unclear.The aim of this study w...

Abstract 3D cell culture models are important tools for the development and testing of new therapeutics. In combination with immunoassays confocal microscopy, crucial information like morphological or metabolic changes can be examined during drug testing. However, a common limitation immunostainings is number dyes that imaged simultaneously, as overlaps in spectral profiles different may result...

BACKGROUND The immunohistochemical assessment of Ki67 antigen (Ki67) is the most widely practiced measurement of breast cancer cell proliferation; however, it has some disadvantages and thus the prognostic value of Ki67 in breast cancer remains controversial. Our previous studies confirmed the advantages of quantum dots-based nanotechnology for quantitative analysis of biomarkers compared with ...

Aim: To characterise a newly developed mouse monoclonal antibody JC1 which recognises a nuclear antigen present in proliferating cells in normal tissues and neoplastic lesions, and which is absent in resting cells. Methods: The methodology was established using a representative range of frozen sections from normal tissues and from certain tumours which were immunostained with antibodies Ki67 an...

The aim of this study was to demonstrate the value of immunocytochemical staining of Ki67 antigen expression in blast cells of children with acute myeloid leukemia (AML) and to evaluate its correlation with treatment failure. The material included bone marrow specimens obtained during induction treatment from 46 children treated for AML between 1998-2003. Immunocytochemical staining for Ki67 wa...

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