Klotho (KL) encodes a single-pass transmembrane protein and is predominantly expressed in the kidney, parathyroid glands, and choroid plexus. Genetic studies on the KL gene have revealed that DNA hypermethylation is one of the major risk factors for aging, diseases, and cancer. Besides, KL exerts anti-inflammatory and anti-tumor effects by regulating signaling pathways and the expression of tar...

a true estimation of gestational age (ga) plays an important role in quality maternity care and scheduling the labor date. this study aimed to evaluate the normal fetal kidney length (kl) and its correlation with ga. a cross-sectional study on 92 pregnant women between 8th and 10th week of gestation with normal singleton pregnancy underwent standard ultrasound fetal biometry and kidney length m...

The current paper primarily aims to suggest a mathematical model for the shape-dependent term of Khan- Liu (KL) Yield/ fracture criterion as a function of Plastic Strain for DP590 steel alloy. The shape-dependent term in the mention criterion can generalize the application of this criterion in order to predict the behavior of other materials. Plane stress case and the first quarter of the stres...

This investigation aimed to assess genetics of body conformation and feed efficiency traits in a control line of Rhode Island Red (RIR) chicken taking single hatched out pedigreed 100 chicks at Central Avian Research Institute, Izatnagar, India. Data was analyzed by least squares analysis of variance. Least squares means of chick weight (CW), body weight (BW), shank length (SL), keel length (KL...

The aim of present experiment was to investigate the feeding value of wild pistachio leaf (khinjuk leaf, KL) for Arabi sheep. The digestibility and fermentation of diets containing different amounts of khinjuk (0, 5, 10, 15, 20, 25 and 30%) were measured. Then, the effect of presence of KL in the diet and its tannin content on the digestibility of alfalfa hay (Alfa), wheat straw (WS) and soybea...

BACKGROUND Homozygous mutant mice with a defect of klotho gene expression (kl/kl) show multiple age-related disorders and premature death from unknown causes. METHODS AND RESULTS The kl/kl mice subjected to 20-hour restraint stress showed a high rate (20/30) of sudden death, which was associated with sinoatrial node dysfunction (conduction block or arrest). Heart rate and plasma norepinephrin...

In the region of large μ+μ− invariant mass, the decay spectrum of KL → μ +μ−γ deviates from the Dalitz pair spectrum, as a result of interference between conversion (KL → γ ∗γ → μ+μ−γ) and bremsstrahlung amplitudes. The latter is proportional to the KL → μ +μ− matrix element, whose 2γ-absorptive part appears to dominate the observed KL → μ +μ− decay rate. We examine the extent to which a scruti...

We recently identified a new gene, klotho, which is involved in the suppression of multiple aging phenotypes. The mouse homozygous for a disruption of the klotho locus (kl/kl) exhibited multiple pathological conditions resembling human aging. Histomorphometric analysis revealed low-turnover osteopenia in kl/kl mice. The decrease in bone formation exceeded that of bone resorption, resulting in a...