1,11-Didechloro-6-methyl-4'-O-demethyl rebeccamycin (JDC-108), a rebeccamycin analog possessing potent anti-tumor activities, was prepared via a concise one-pot strategy in good yield. The interaction between JDC-108 and human serum albumin (HSA) was studied by spectroscopic methods including fluorescence spectroscopy, UV-vis absorption spectrum, and molecular modeling. The quenching mechanism ...

The research aim was to predict the bus operators' blood pressure (BP) and psychological strain using a combination of the Job-Demand Control (JDC) and Effort-Reward Imbalance (ERI) models. The study was conducted with a sample of 139 bus operators in the city of Bogotá (Colombia), who answered a questionnaire that included the Job Content Questionnaire (JCQ), the ERI Questionnaire, and the Gen...

El 20 de febrero 2019 el Tribunal Constitucional Electoral mexicano resolvió juicio para protección los derechos político-electorales del ciudadano (JDC) SUP-JDC-352/2019 y acumulado, acción presentada por las Personas Humanas identificada como “Actores” Guadalupe Gómez Hernández Marcos Ruiz López. De una interpretación evolutiva reconoció la inexistencia mecanismo alguno que garantizará voto a...

OBJECTIVES The aim was to investigate whether psychosocial stress based on the job-demand-control (JDC) model increased the risk for coronary heart disease (CHD) and stroke. SETTING Swedish men. PARTICIPANTS The Primary Prevention Study (PPS) comprises 6070 men born between 1915 and 1925 free from previous history of CHD and stroke at baseline (1974-1977). Psychosocial workplace exposure wa...

BACKGROUND This cross-sectional study explored relationships between psychosocial work environment, captured by job demand-control (JDC) and effort-reward imbalance (ERI), and seven cardiovascular heart disease (CHD) risk factors in a general population. METHOD The sampled consists of randomly-selected men and women from Gothenburg, Sweden and the city's surrounding metropolitan areas. Associ...

The operation of a dual-free-layer (DFL) spin-torque nano-oscillator (STNO) is studied is demonstrated that in a practically interesting regime when the magnetizations of the two free layers (FLs) precess in opposite directions along large-angle out-of-plane trajectories, thus doubling the generation frequency, the operation of the DFL STNO is strongly hysteretic as a function of a bias dc curr...

The aim of the present study was to identify relations between occupational stress and occupational class in Japanese civil servants, using two occupational stress models-the Effort-Reward Imbalance (ERI) Model and the Job Demand-Control (JDC) Model. The subjects were employees of three local public organizations. We distributed self-administered questionnaires and assessed occupational stress ...

Juvenile drug court (JDC) programs have expanded rapidly over the past twenty years and are an increasingly popular option for rehabilitating juvenile offenders with substance use problems. Given the high cost of crime to society, an important economic question is whether and to what extent JDC programs reduce criminal activity among juvenile offenders. To address this question, the present stu...