subarachnoid hemorrhage (sah) resulting from a ruptured intracranial aneurysm can induce cerebral vasospasm with subsequent reduction in cerebral blood flow (cbf). the present study examines the pathological alterations in the wall of human cerebral arteries at autopsy, especially with regard to intimal pathology, following aneurysmal sah. arterial segments from the circle of willis were fixed ...

BACKGROUND Detection of transplant coronary disease remains difficult. Both intravascular ultrasound (IVUS) imaging and functional coronary vasomotion studies have been used to evaluate this process. However, the time course of intimal thickening as assessed by IVUS and the relation between structure and function have not been explored. METHODS AND RESULTS In 40 patients 1 to 8 years after tr...

Recent studies have established that age is the major risk factor for vascular disease. Numerous aberrant changes occur in vascular structure and function during aging, and animal models are the primary means to determine the underlying mechanisms of age-mediated vascular pathology. The Fischer 344/Brown Norway F1 hybrid (F344xBN) rat thoracic aorta has been shown to display age-related patholo...

INTRODUCTION Pulmonary artery intimal sarcoma is a rare disease with no characteristic symptoms. It is difficult to diagnose early and is frequently misdiagnosed as a pulmonary embolism. CASE PRESENTATION Here we report a case of pulmonary artery intimal sarcoma in a 54-year-old woman presenting with complaints of shortness of breath on exertion. Echocardiography and a computed tomography sca...

Subarachnoid hemorrhage (SAH) resulting from a ruptured intracranial aneurysm can induce cerebral vasospasm with subsequent reduction in cerebral blood flow (CBF). The present study examines the pathological alterations in the wall of human cerebral arteries at autopsy, especially with regard to intimal pathology, following aneurysmal SAH. Arterial segments from the circle of Willis were fi...

BACKGROUND Coronary atherosclerosis has been demonstrated in young adults by postmortem pathology. Angiographic evaluation of coronary disease in young adults is limited by ethical issues and the insensitivity of angiography for detecting early pathology. Catheter-based intracoronary ultrasound has proven useful both in detecting and quantitating coronary disease, but the ultrasound appearance ...

A 66-year-old female with a 1-month history of increasing fatigue, dyspnea on exertion, and palpitations presented clinical signs heart failure. Chest computed tomography (CT) revealed large, mobile left atrial (LA) mass attached to the mitral valve causing severe stenosis regurgitation. The was surgically debulked replaced. Pathology poorly differentiated malignant spindle cell neoplasm diffus...

Pulmonary artery intimal sarcoma is a highly aggressive disease, and is most often misdiagnosed as pulmonary thromboembolism (PTE) due to the similar clinical symptoms and its rarity, which leads to the use of inappropriate treatments such as prolonged anticoagulant therapy. We reported a case of pulmonary artery intimal sarcoma in a patient who was misdiagnosed as having PTE. Pathology after s...

Spontaneous renal artery dissection is a rare but important cause of flank pain. We report a case of isolated spontaneous renal artery dissection in 56-year-old man complicated by renal infarction presented with flank pain. Doppler study pointed towards vascular pathology. Computed tomography (CT) angiography was used to make final diagnosis which demonstrated intimal flap in main renal artery ...

The immediate-early gene product and zinc finger transcription factor early growth response (Egr)-1 plays a key master regulatory role in multiple cardiovascular pathological processes. This article reviews the amazing recent evidence implicating Egr-1 in atherosclerosis, intimal thickening after acute vascular injury, ischemic pathology, angiogenesis, allograft rejection, and cardiac hypertrophy.