نتایج جستجو برای: interferon gamma receptor
تعداد نتایج: 720250 فیلتر نتایج به سال:
we have reviewed the medical records of 40 patients with disseminated (bacille calmette-guerin) bcg from 1996 to 1999 in the immunology department of the children hospital, medical center, tehran university. these patients are divided in to 3 groups: 1. patients who had disseminated (bacille calmette-guerin) bcg after vaccination and their diagnosis was chronic granulomatous disease. 2. patient...
background and aims: chronic hbv infection is one of the most common viral infections in worldwide which many factors such as genetic factors are involved in pathogenesis of disease. gamma interferon (ifn-γ) and its receptor (infgr) play a critical role in the immune response to hbv infection. single nucleotide polymorphisms (snps) are effective on level of gene expression, the aim of this stud...
it is now well documented that interferon gamma (ifn-γ) is the indispensable cytokine for inducing protective immunity against experimental and human cutaneous leishmaniaisis. the importance of ifn-γ receptor (ifn-γr) has also been studied. in the present study, we made attempts to find out whether l. major infection is able to alter the expression of ifn-γr in vivo. in addition, we studied the...
Abstract Background and objectives: Interferon-Gamma and interferon Gamma receptor (IFNγ ⁄ IFNγR1) are the main genes associated with susceptibility to tuberculosis. We aimed at studying on interferon-Gamma Gene polymorphism(- 56 C/T) in people suffered from tuberculosis (TB). Material and Methods: In this case-control study, the subjects were 62 individuals with TB and 74 hea...
background chronic hepatitis b virus (hbv) infection is a multifactorial disease that can result in serious clinical complications. host genetic background especially the genes that encode immunologic factors like inf-γ and its receptor (ifn-γ r) are critical in the pathogenesis of infection. materials and methods genomic dna from peripheral blood samples of 200 chronically hbv infected patient...
We investigated which is the shortest fragment of the interferon gamma receptor with ligand binding capacity. A recombinant soluble interferon gamma receptor produced in Escherichia coli was subjected to controlled digestion with several proteolytic enzymes. The fragments generated were assayed by four approaches for interferon gamma binding. A 25-kDa polypeptide comprising residues 6-227 of th...
Background & Aims: It has been shown that some drugs such as Pentoxifylline (PTX) have immunomodulatory and anti-inflammatory activity that might represent a potential preventive therapy for autoimmune diseases. The purpose of this study was to investigate the therapeutic effects of pentoxifylline on the treatment of autoimmune diabetes in mice and its effects on expressions of peroxisome proli...
We purified and characterized a soluble human interferon gamma receptor expressed in Escherichia coli. The soluble receptor comprises the amino acids 15-246 of the encoded protein (Aguet, M., Dembic, Z., and Merlin, G. (1988) Cell 55, 273-280) and was purified from large scale fermentations through four chromatographic steps with an overall recovery of 28%. The refolded soluble receptor shows s...
Background: All-trans retinoic acid (ATRA) has a variety of biological activities, including immunomodulatory action in a number of inflammatory and autoimmune diseases. The purpose of this study was to investigate the effects of all-trans retinoic acid on the treatment of autoimmune diabetes in mice and its effects on expressions of Peroxisome Proliferator-Activated Receptor gamma (PPARγ...
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