objective: hyperglycemia is associated with increased morbidity and mortality in diabetic patients following coronary artery bypass grafting. tight glycemic control in perioperative period can reduce these events. the goal of this study was to determine whether combination of continuous infusion and subcutaneous glargine as a basal insulin could improve glycemic control. material and methods: d...

conclusions it seems that in people with type 2 diabetes, acute aerobic exercise can decrease the plasma levels of glucose, possibly through increasing orexin a. in addition, negative energy balance is necessary to decrease the levels of insulin and insulin resistance during acute aerobic exercise. results the analysis of findings in p ≤ 0.05 indicated that acute aerobic exercise caused a signi...

effects of insulin (1, 2 and 3 iu/kg, i.p.), morphine (5mg/kg, i.p.), naloxone (5mg/kg, s.c.), insulin before morphine and after naloxone were studied in the formalin test of mice. formalin test was induced by intraplantar injection of formalin (20m, 5%). morphine alone and insulin with morphine decreased the first phase (0-5 min) of pain. naloxone increased the interphase (6-20 min) of nicicep...

background: obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases.  the aim of this study was to examine the association of insig2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in north indian subjects. methods: the variants were investigated ...

context since 2006 a relevant number of therapeutical algorithms for the management of type 2 diabetes have been proposed, generating a lively debate in the scientific community, particularly on the ideal timing for introduction of insulin therapy and on which drug should be preferred as add-on therapy in patients failing to metformin. at the moment, there is no real consensus. the aim of the p...

diabetes mellitus is a group of metabolic diseases. insulin resistance is defined as a state that needs more insulin to get the biological effects achieved by a lower amount of insulin in the normal state. several molecules which are secreted through adipocytes have been involved in insulin resistance and type 2 diabetes mellitus. adiponectin as a 244 amino acid protein is exclusively expressed...

background: diabetes mellitus is one of the most important diseases in all over the world. insulin and its receptor are found in specific area of cns with a variety of regions-specific functions different from its role in direct glucose regulation in the periphery. the hippocampus and cerebral cortex distributed insulin and insulin receptor has been shown to be involved in brain cognitive funct...

Abstract Type 1 diabetes occurs when autoreactive T cells attack insulin-producing in pancreatic islets. B promote disease by acting as essential antigen presenting cells. Targeted immune therapy for treatment and prevention of autoimmune diseases is preferable to drugs that cause global immunosuppression. We therefore investigated the efficacy three constructs designed specifically target neut...