background: leishmaniasis has been identified as a major public health problem in tropical and sub-tropical countries. the present study was aimed to investigate antileishmanial effects of various extracts of berberis vulgaris also its active com-poenent, berberine against leishmania tropica and l. infantum species on in vitro ex-periments. methods : in this study in vitro antileishmanial activ...

Background:Punica granatum var. pleniflora (PGP) has been used for thousands of years as an effective agent to treat various types of diseases. However, there are a few new evidences addressing its therapeutic effects and related mechanisms. Therefore, the aim of this study was to investigate the cytotoxic, antioxidant, antibacterial, and anti-inflammatory effects of ethanolic (ET), dichloromet...

There has been a growing interest in the design of environmentally affable and biocompatible nanoparticles among scientists to find novel and safe biomaterials. Panax ginseng Meyer berries have unique phytochemical profile and exhibit beneficial pharmacological activities such as antihyperglycemic, antiobesity, antiaging, and antioxidant properties. A comprehensive study of the biologically act...

Artocarpus hirsutus Lam. belongs to Moraceae family and is endemic to Western Ghats and Kerala in India. This species is found to be effective in traditional medicine for the treatment of ulcer, diarrhea and pimples. However, extensive biological evaluation on each component of this specific species rarely appears in the literature which restricts its applicability as medicinal herb. The leaf, ...

Research background. The cytotoxicity on various vital cell lines and the activity foodborne pathogens (murine norovirus 1 as a surrogate Campylobacter jejuni) of methanolic Urtica dioica L. leaf extract (UDE) were studied. Experimental approach. cytotoxic concentration 50% (CC50) was measured by linearity between UDE concentrations viability. Antibacterial effects C. jejuni analyzed broth micr...

Chronic inflammation can lead to several diseases that represent the leading causes of mortality worldwide. Conventional treatment carry some risks. Therefore, research on herbal medicine are suspected having anti-inflammatory effects, such as Piper betle L., is important. This study aims investigate effect P. L. extract nitric oxide a pro-inflammatory mediator. The dried leaves were extracted ...

introduction: one of the major contributing factors, which may cause failure of endodontic treatment, is the presence of residual microorganisms in the root canal system. for years, most dentists have been using calcium hydroxide (ch) as the intracanal medicament between treatment sessions to eliminate remnant microorganisms. reducing the size of ch particles into nanoparticles enhances the pen...

Two polyenylpyrroles from a soil ascomycete Gymnoascus reessii were previously identified as hit compounds in screening for cytotoxicity against lung cancer cells. These compounds and various analogs, which have been previously synthesized and tested for anti-lung cancer cell activity, were tested for anti-inflammatory activity. After preliminary screening for cytotoxicity for RAW 264.7 murine ...

The current in vitro study was designed to investigate the anti-inflammatory, cytotoxic and antioxidant activities of boesenbergin A (BA), a chalcone derivative of known structure isolated from Boesenbergia rotunda. Human hepatocellular carcinoma (HepG2), colon adenocarcinoma (HT-29), non-small cell lung cancer (A549), prostate adenocarcinoma (PC3), and normal hepatic cells (WRL-68) were used t...

Macrophage colony-stimulating factor (M-CSF)' is one of several cytokines that control the differentiation of monocytes and macrophages. In human and murine bone marrow cultures it stimulates the proliferation and differentiation of macrophage progenitors (1, 2), and it has been shown to exert a similar effect on murine pulmonary macrophages in vitro (3). Murine peritoneal macrophages exposed t...