In living cells, proteins are dynamically connected through biochemical reactions, so its functional features are properly encoded into proteinprotein interaction networks (PINs). Up to present, many efforts have been devoted to exploring the basic feature of PINs. However, it is still a challenging problem to explore a universal property of PINs. Here we employed the complex networks theory to...

The effect of through-thickness reinforcement by thin 1 mm steel needles (z-pins) on the static tensile strength of double-lap joints of a carbon/epoxy composite was investigated. Two types of joints-z-pinned and hybrid (including glued ones)-were considered. The joints were reinforced in the overlap region with 9, 25, or 36 z-pins. Comparing mechanical properties of the double-lap joints with ...

Protein interaction networks (PINs) are often used to "learn" new biological function from their topology. Since current PINs are noisy, their computational de-noising via link prediction (LP) could improve the learning accuracy. LP uses the existing PIN topology to predict missing and spurious links. Many of existing LP methods rely on shared immediate neighborhoods of the nodes to be linked. ...

Computationally complex and data intensive atomic scale biomolecular simulation is enabled via processing in network storage (PINS): a novel distributed system framework to overcome bandwidth, compute, storage, organizational, and security challenges inherent to the wide-area computation and storage grid. PINS is presented as an effective and scalable scientific simulation framework to meet the...

Drosophila neuroblasts divide asymmetrically by aligning their mitotic spindle with cortical cell polarity to generate distinct sibling cell types. Neuroblasts asymmetrically localize Galphai, Pins, and Mud proteins; Pins/Galphai direct cortical polarity, whereas Mud is required for spindle orientation. It is currently unknown how Galphai-Pins-Mud binding is regulated to link cortical polarity ...

Asymmetric cell division is a fundamental mechanism used to generate cellular diversity in invertebrates and vertebrates. In Drosophila, asymmetric division of neuroblasts is achieved by the asymmetric segregation of cell fate determinants Prospero and Numb into the basal daughter cell. Asymmetric segregation of cell fate determinants requires an apically localized protein complex that includes...

Drosophila neuroblasts divide asymmetrically by aligning their mitotic spindle with cortical cell polarity to generate distinct sibling cell types. Neuroblasts asymmetrically localize G i, Pins, and Mud proteins; Pins/G i direct cortical polarity, whereas Mud is required for spindle orientation. It is currently unknown how G i–Pins–Mud binding is regulated to link cortical polarity with spindle...

To ensure that users do not choose weak personal identification numbers (PINs), many banks give out system-generated PINs, using computers to generate random PINs. 4-digit is the most commonly used PIN length, but 6-digit system-generated PINs are also becoming popular. The increased security we get from using system-generated PINs, however, comes at the cost of memorability. And while banks ar...

Asymmetrically localized PIN-FORMED (PIN) auxin efflux carriers play key roles in regulating directional intercellular auxin movement, generating local auxin gradients, and diverse auxin-mediated growth and development. The polar localization of PINs is controlled by phosphorylation in the central hydrophilic loop (HL) of PINs. Although the M3 phosphorylation site, including phosphorylatable 5 ...