A biophysical analysis of the voltage-gated K (Kv) currents of frog saccular hair cells enzymatically isolated with bacterial protease VIII was carried out, and their contribution to the cell electrical response was addressed by a modeling approach. Based on steady-state and kinetic properties of inactivation, two distinct Kv currents were found: a fast inactivating IA and a delayed rectifier I...

Trigeminal ganglion (TG) neurons are functionally and morphologically heterogeneous, and the molecular basis of this heterogeneity is still not fully understood. Here we describe experiments showing that a subpopulation of neurons expresses a delayed-rectifying K(+) current (IDRK) with a characteristically high (nanomolar) sensitivity to the dihydroquinoline CP339,818 (CP). Although submicromol...

having briefly been reviewed the historical process of changing the formulae for determining the times of islamic prayers, two newly found formulae and a new rule for establishing the times of prayers would be discussed. these matters have been exploited from four texts, still preserved as manuscript: (1) siyyid ¾?y? al-d?n sh?shtar?’s ¼ad b?b dar macrifa al-a½??rl?b, (2) b?r?n?’s ’ist?c?b f? c...

How infants learn language is one of the great scientific questions of our time. While traditional nativist views of language development rely on predetermined, innate modules to explain the infant’s ability to acquire complex language systems in a short amount of time, learning perspectives have more recently turned to domain-general processes to explain this phenomenon. As it turns out, there...

We thank Tomao et al for their comments on our recent report on patient-reported outcomes (PROs) in the Suppression of Ovarian Function Suppression Trial (SOFT). When SOFTwas designed more than a decade ago to investigate the role of ovarian function suppression (OFS) and the role of exemestane in premenopausal women with endocrine-responsive early breast cancer either after completion of (neo)...