Background and Aims. Women with former gestational diabetes (fGDM) are characterized by impaired beta-cell function (BC). Incretin hormones contribute to insulin secretion after oral administration of glucose. We aimed to assess the possible role of incretins on altered insulin release in fGDM. Materials and Methods. We studied 104 fGDM women within 6 months after delivery and 35 healthy women ...

The dynamics of inhibitory circuits in the cortex is thought to rely mainly on synaptic modifications. We challenge this view by showing that hippocampal parvalbumin-positive basket cells (PV-BCs) of the CA1 region express long-term (>30 min) potentiation of intrinsic neuronal excitability (LTP-IE(PV-BC)) upon brief repetitive stimulation of the Schaffer collaterals. LTP-IE(PV-BC) is induced by...

BACKGROUND Dyskinesias are a frequent adverse effect of long-term levodopa therapy. The relative contribution of dopamine D(1) and D(2) receptor function to the pathophysiology of levodopa-induced dyskinesias remains a matter of controversy. OBJECTIVE To establish whether a selective D(1) dopamine agonist induces more or less dyskinesia than levodopa in primed dyskinetic patients with Parkins...

MIC and disk diffusion quality control (QC) ranges were established for two new pleuromutilin antimicrobials (BC-3205 and BC-3781) in an eight-laboratory study performed according to Clinical and Laboratory Standards Institute M23-A3 guidelines. Staphylococcus aureus ATCC 29213 and 25923, Streptococcus pneumoniae ATCC 49619, and Haemophilus influenzae ATCC 4927 strains were evaluated. The propo...

Although bucolome has been used empirically to enhance and stabilize warfarin action in some institutes, the clinical risks and benefits of this combination are unclear. In the present study, warfarin monotherapy (WM) and bucolome combination (BC) therapy were compared in anticoagulation therapy.One hundred and ninety-five patients indicated for anticoagulation therapy were randomly assigned to...

t(14;18) is the most common translocation in human lymphoid malignancy and results in bcl-2 overexpression. bcl-2 blocks apoptosis and constitutes the initial member of a new catagory of oncogenes, ie, regulators of cell death. Bc/-2-/g transgenic mice develop follicular hyperplasia and progress to malignant B-cell lymphoma. To assess the oncogenic potential of bcl-2 in the T-cell lineage, a ...

Binary neural networks (BNNs) have been proposed to reduce the heavy memory and computation burdens in deep networks. However, binarized weights activations BNNs cause huge information loss, which leads a severe accuracy decrease, hinders real-world applications of BNNs. To solve this problem, paper, we propose information-enhanced network (IE-Net) improve performance Firstly, design an binary ...

n-propylsalicylidene based on silica as ion exchanger (ie) was used for the separation by complexation of mn2+, co2+, ni2+, cu2+, hg2+, cr3+, fe3+, and uo22+ from their parent solutions. ie and its metal complexes are characterized by elemental analysis, electronic and infrared spectra, in addition to thermal analysis in atmospheric pressure. the mode of chelation and the proposed geometric str...

CrystEngComm COMMUNICATION Bettina V. Lotsch et al. Optical gap in herringbone and π-stacked crystals of [1]benzothieno[3,2-b] benzothiophene and its brominated derivative

OBJECTIVE To compare the sensitivity of 3 different criteria-von Reyn, Duke, and modified Duke-in diagnosing infective endocarditis (IE) in children. STUDY DESIGN Retrospective case study in a tertiary pediatric hospital. METHODS AND RESULTS Between 1985 and 2001, 41 episodes of IE were documented in 40 children (median: 7 years old; range: 1 week to 18 years). The diagnosis was based on ec...