the effect of alkyl substituents on the c-phenyl and/or the n-phenyl ring of benzophenylhydroxamic acid on their molecular structure and hydrogen bonding has been investigated. the predominant configuration in chcl3 is determined by steric and electronic effects. substituents on the c-phenyl ring favor the cis configuration, while substituents in the n-phenyl ring favor a trans configuration. t...

Nocardia 107-332, a soil isolate, oxidizes short-chain alkyl-substituted cyclic hydrocarbons to cyclic acids while growing on n-alkanes. Cyclic acids are produced also from relatively long-chain alkyl-substituted cyclics such as n-nonylbenzene or n-dodecylbenzene which alone support growth in a mineral-salts medium. omega-Oxidation of the alkyl substituents is followed by beta-oxidation. It is ...

Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1' substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold selectivity for MMP-13 versus MMP-2 and -8.

An unprecedented highly diastereoselective and enantioselective aldol reaction of α-alkyl azlactones and aliphatic aldehydes was achieved with cinchona alkaloid catalysts. To our knowledge, this reaction provides the first useful catalytic asymmetric access toward β-hydroxy-α-amino acids bearing alkyl substituents, which are structural motifs embedded in many natural products.

Gas-phase acidities of 15 aliphatic carboxylic acids, X CH -,COOH, have been calculated using the MNDO method. Among the substituted groups exist the electron donor alkyl groups and electron acceptor halogens. The average error in acidity is within the experimental uncertainty of the data. Systematic errors have been found for the substituents which form internal hydrogen bondings. A reaso...

Alkyl chloroformates with methyl, ethyl, and 2-chloroethyl substituents can instantaneously esterify fatty acids under proper reaction conditions. Apart from the formation of the corresponding alkyl esters, even the alkoxycarbonyl esters can be prepared. These derivatives are useful for the analysis of short-chain fatty acids. As alkoxycarbonyl ester, even acetic acid can already be separated f...

Naturally occurring hydroxamic acids and hydroxamates are reviewed and classified according to the chemistry of the hydroxamic acid functions. The identity of the Fe(m) trihydroxamate albomycin ö2 with antibiotic Ro 5-2667 is established. TABLE OF CONTENTS 1. Monohydroxamic acids 1.1. Linear hydroxamic acids 1.1.1. Primary hydroxamic acids 1.1.2. Secondary hydroxamic acids 1.2. Cyclic hydroxami...

Titanium raw materials are widely used for the synthesis of various functional – sorbents radionuclides and rare earth elements, additives, filler pigments, etc. Since most titanium concentrates imported, in line with import substitution program, production titanite concentrate from apatite-nepheline ores Khibiny deposits is a promising trend supplying national industry materials. The article p...

The activities are reported of sodium salts of several n-alkylsalicylic acids against Staphylococcus aureus, Pseudomonas aeruginosa, Mycobacterium phlei, and Candida albicans. The acids had alkyl substituents of 1 to 18 carbon atoms in the 3, 4, or 5 positions relative to the carboxyl group of salicylic acid. Generally, the antimicrobial properties were typical of anionic surface-active agents ...

In this study, the adsorption behavior of the primary, secondary and tertiary alcohols over nanoscale (1 0 0) surface of defect spinel γ-alumina was investigated with the aid of density functional theory (DFT) at BLYP/DNP level of calculation. The influence of different substituents including alkyl, cycloalkyl, allyl and aryl were analyzed for free and adsorbed alcohols to shed light the adsorp...